Influence of fibrinogen β-chain gene variations on risk of myocardial infarction in a Chinese Han population  

作　　者：LU Xiang-feng YU Hong-jiang ZHOU Xiao-yang WANG Lai-yuan HUANG Jian-feng GU Dong-feng 

机构地区：[1]Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China [2]National Human Genome Center at Beijing, Beijing 100176, China

出　　处：《Chinese Medical Journal》2008年第16期1549-1553,共5页中华医学杂志（英文版）

基　　金：This work was supported by grants from the Hi-tech Research and Development of China （No. 2006AA020706, 2006AA02Z170） and from Beijing Natural Science Foundation （No. 7061006）.

摘　　要：Background Although the role of fibrinogen as a predictor of acute myocardial infarction （MI） has been well-established, the association of genetic polymorphisms in the fibrinogen gene with MI is still controversial. This study was conducted to elucidate the association between the genetic polymorphisms of the fibrinogen β-chain （FGB） gene and MI in Chinese Han population. Methods The occurrence of 3 common polymorphisms （i.e. -455G/A, R448K and 8558C/G） in a case-control study including 508 patients with MI and 503 healthy controls was investigated. Results Analyses of single polymorphisms showed that individuals carrying the rare alleles for the 3 polymorphisms were significantly associated with a decreased risk of MI. Logistic regression analysis indicated that R448K remained independently associated with MI after adjustment for environmental risk factors （adjusted odds ratio（OR） =0.71 for KK/RK versus RR, P=0.023）. The three polymorphisms were found to be in strong linkage disequilibrium. Haplotype analyses showed that the A-K-G haplotype （-455A, 448K, 8558G） was associated with a protective effect against MI. Compared with the common haplotype G-R-C, the adjusted OR for A-K-G was 0.68 （95% CI, 0.51 - 0.90; P=-0.006）. Conclusion These data indicate that individuals carrying the FGB 448K allele may be protective against having MI in this population.Background Although the role of fibrinogen as a predictor of acute myocardial infarction （MI） has been well-established, the association of genetic polymorphisms in the fibrinogen gene with MI is still controversial. This study was conducted to elucidate the association between the genetic polymorphisms of the fibrinogen β-chain （FGB） gene and MI in Chinese Han population. Methods The occurrence of 3 common polymorphisms （i.e. -455G/A, R448K and 8558C/G） in a case-control study including 508 patients with MI and 503 healthy controls was investigated. Results Analyses of single polymorphisms showed that individuals carrying the rare alleles for the 3 polymorphisms were significantly associated with a decreased risk of MI. Logistic regression analysis indicated that R448K remained independently associated with MI after adjustment for environmental risk factors （adjusted odds ratio（OR） =0.71 for KK/RK versus RR, P=0.023）. The three polymorphisms were found to be in strong linkage disequilibrium. Haplotype analyses showed that the A-K-G haplotype （-455A, 448K, 8558G） was associated with a protective effect against MI. Compared with the common haplotype G-R-C, the adjusted OR for A-K-G was 0.68 （95% CI, 0.51 - 0.90; P=-0.006）. Conclusion These data indicate that individuals carrying the FGB 448K allele may be protective against having MI in this population.

关 键 词：association study fibrinogen β-chain genetic polymorphism HAPLOTYPE myocardial infarction 

分 类 号：R543[医药卫生—心血管疾病]