MRI监控高强度聚焦超声损伤离体肝脏的影像学研究  

Imaging study of MRI-guided high intensity focused ultrasound damage of liver tissues in vitro

作　　者：沈洁[1] 邹建中[1] 申俊玲[1] 刘映江[1] 胡晓[1] 董洁[1] 王智彪[1] 

机构地区：[1]重庆医科大学医学超声工程研究所,重庆400016

出　　处：《重庆医科大学学报》2008年第8期907-910,共4页Journal of Chongqing Medical University

基　　金：国家杰出青年基金资助(No:30325027)

摘　　要：目的:观察高强度聚焦超声(High intensity focused ultrasound,HIFU)损伤离体肝组织的MRI监控图像变化,探讨MRI监控的有效性和准确性。方法:通过MRI监控HIFU辐照离体牛肝组织,观察不同剂量损伤灶的MRI图像,以及与实际损伤面积的关系。结果:本研究共计60例损伤灶,其中50例(83.3%)损伤灶于PDWI和T2WI中表现为边界清晰的稍低信号,与实际损伤面积比较无统计学差异(P>0.05)。而在T1WI中仅23例(38.3%)可见信号增高。结论:本研究证实我所自行研制的MRI监控HIFU设备能有效监控治疗,准确评价疗效,并为后期治疗肝脏肿瘤提供一定的影像学基础。Objective：To observe the liver tissue in vitro damaged by high intensity focused uhrasound（HIFU）using MRI, and evaluate the validity and accuracy of MRI-guided treatment. Methods：Calf liver tissues in vitro were exposed to MRI-guided HIFU with different intensity and duration. The lesions on MRI imaging were compared with the actual necrotic foci. Results： 60 lesion images were inspected,50 lesions（ 83.3% ）on T2WI and PDWI had low signals with clear border, and the lesion area on T2WI and PDWI highly correlated with the actual necrotic area（P〉0.05）. But only 23 lesions（38.3%）showed high signal on T1WI. Conclusion：This research confirmed the MRI-guided HIFU equipment is useful to monitor the HIFU treatment and evaluate the curative effect accurately,which provids a basis for the latter treatment of liver tumors.

关 键 词：高强度聚焦超声 MRI 肝脏 

分 类 号：R730.59[医药卫生—肿瘤]