^(99m)Tc-MDP骨扫描和肿瘤标记物对非小细胞肺癌分期诊断的价值  

The value of combination ^(99m)Tc-MDP bone scanning with serum tumor marker measurement in the stages of non-small lung cancer

作　　者：冯雪凤[1] 贾支俊[1] 施鸣 许守林[1] 郭万华[1] 

机构地区：[1]南京大学医学院附属鼓楼医院核医学科,江苏南京210008

出　　处：《现代肿瘤医学》2008年第9期1512-1514,共3页Journal of Modern Oncology

摘　　要：目的:研究99mTc-MDP骨扫描和肿瘤标记物在非小细胞肺癌分期诊断中的价值。方法:对156例初诊非小细胞肺癌患者行99mTc-MDP骨扫描,并收集肺癌患者和30例正常人的血清标本,用化学发光法检测CEA、CA125、NSE和CYFRA21-1四项指标。结果:病人CEA、CA125、NSE和CYFRA21-1高于正常人(P<0.01),并且随着期别进展,肿瘤标记物水平逐步升高。99mTc-MDP骨扫描明确骨转移的占25.64%(40/156),Ⅳ期81例患者48.12%(39/81)发生骨转移。结论:99mTc-MDP核素骨扫描可作为肺癌分期检查的筛查手段;随着肺癌病程的进展,肿瘤标记物CEA、CA125、NSE和CYFRA21-1的水平逐渐上升。99mTc-MDP骨扫描联合肿瘤标记物在非小细胞肺癌分期诊断中具有重要的价值。Objective： To study the value of combination 99mTc - MDP bone scanning with serum tumor marker measurement in the stages of patients with non - small lung cancer. Methods： 99mTc - MDP whole - body bone scan- ning was performed in 156 patients with non - small lung cancer, the serum samples were collected in 156 patients and 30 comparison controls. CEA, CA125, NSE and CYFRA21 -1 were measured by chemiluminescence technique. Results： In 156 patients with non- small lung cancer, Ⅰ stage patients were 6. 41% （ 10/156 ） , Ⅱ stage patients 5.77% （9/156）, Ⅲ stage patients 15.38% （24/156）, Ⅳ stage patients 51.92% （81/156） ,unknowable stage patients 20.51% （32/156）. The average value of CEA and CYFRA21 - 1 in I stage patients was higher than the control group（ P 〈 0.05 ）. CEA, CA125, NSE and CYFRA21 -1 inⅡ stage patients was higher than the control group （P 〈 0.01 ）. Following the stage advancement the revel of these serum tumor marker was higher and higher. The positive ratio of patietens with osseous metastasis was confirmed by 99mTc - MDP whole - body bone scanning was 25.64% （40/156）, 48.12% （39/82） patients osseous metastasized in 82 IV stage patients. Conclusion： 99mTc- MDP bone scanning was considerable in the stages of lung cancer, following the stage advancement CEA, CA125, NSE and CY- FRA21 - 1 was higher and higher. Combination 99mTc - MDP bone scanning with serum tumor marker measurement are valuable to the stage diagnosis of non - small lung cancer.

关 键 词：骨扫描 非小细胞肺癌 CEA CA125 NSE CYFRA21—1 

分 类 号：R734.2[医药卫生—肿瘤]