力比泰联合顺铂治疗30例恶性胸膜间皮瘤的疗效观察  

Curative effect of Alimta combined with platinum complexes in the treatment of 20 patients with malignant pleural mesothelioma

作　　者：蒋伟[1] 孙秀威[2] 陈玉玲[2] 

机构地区：[1]哈尔滨工程大学医院,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属肿瘤医院,黑龙江哈尔滨150040

出　　处：《现代肿瘤医学》2008年第9期1536-1538,共3页Journal of Modern Oncology

摘　　要：目的:探讨力比泰(培美曲塞)联合顺铂治疗恶性胸膜间皮瘤(MPM)的疗效和毒副作用。方法:30例恶性胸膜间皮瘤患者采用力比泰联合顺铂全身化疗,其中力比泰500mg/m2第一天静脉点滴,顺铂20mg/m2,第1-5天静脉点滴,21天为1周期,一般3-4周期。观察近期疗效、远期疗效、毒副作用、中位缓解期和中位生存期。结果:30例患者中,CR4例,PR13例,SD7例,NC6例。总有效率56.7%(17/30),中位缓解期6.8个月,中位生存期11.9个月,毒副作用:白细胞减少发生率为30%(9/30),III度-Ⅳ度10%(3/30),血小板减少发生率10%(3/30),皮疹发生率30%(9/30),低热发生率20%(6/30),口腔炎发生率为20%(6/30),其它尚包括恶心、呕吐、疲劳、嗜睡和厌食等。所有毒副作用经对症处理和支持治疗后均恢复正常。结论:力比泰联合顺铂治疗恶性胸膜间皮瘤疗效较好,毒副作用较轻,值得临床推广。Objective： To evaluate the efficacy and toxicity and side effects of malignant pleural mesothelioma （MPM） treated with Alimta （ pemetrexed ） and cisplatin. Methods： Thirty cases of patients with malignant pleural mesothelioma were treated by the systemic chemotherapy combined with cisplatin and Alimta. Alimta was administered at the dose of 500mg/m^2, iv , day 1. Cisplatin 20mg/m^2, iv, day 1 -5, every there weeks. Results： There were 4 complete remission, 13 partial responses,7 no changes,6 progressive diseases. The total efficiency rate was 56.7% （17/30）,the median durations of response and survival were 6.8 and 11.9 months respectively. The main toxicity were：neutropenia 30% ,Ⅲ° -Ⅳ° 10% ,thrombocytopenia 10% ,skin rash 30% ,low- grade fever 20% ,stomatitis 20% , the others including nausea, vomiting, fatigue, lethargy and anorexia. All adverse reactions were cured after treatment. Conclusion： Were treated by Alimta（pemetrexed） and cisplatin is effective and with less toxic and side effects in the treatment of malignant pleural mesothelioma.

关 键 词：恶性胸膜间皮瘤 力比泰 顺铂 

分 类 号：R734[医药卫生—肿瘤]