^(11)C-胆碱与^(18)氟去氧葡萄糖PET/CT显像在肺癌诊断中的对比研究  

Comparison of ^(11)C-choline and ^(18)FDG PET/CT imaging in the diagnosis of pulmonary carcinoma

作　　者：常林凤[1] 卢光明[2] 朱虹[1] 张宗军[2] 胡裕效[1] 季发权[1] 薛杨波[1] 

机构地区：[1]南方医科大学南京临床医学院(南京军区南京总医院)核医学科,江苏南京210002 [2]南方医科大学南京临床医学院(南京军区南京总医院)医学影像科,江苏南京210002

出　　处：《医学研究生学报》2008年第8期823-827,共5页Journal of Medical Postgraduates

基　　金：国家973计划基金资助项目(批准号:2006CB705707)

摘　　要：目的:通过11C-胆碱(11C-choline)与18氟去氧葡萄糖(18FDG)PET/CT显像对肺癌的对比研究,探讨11C-胆碱PET/CT显像对肺癌的诊断价值,并对其相关性进行研究。方法:21例肺癌患者行11C-胆碱及18FDG PET/CT显像,分别分析11C-胆碱及18FDG PET/CT图像,计算标准摄取值(SUV)、瘤/非瘤(T/N)组织,对11C-胆碱及18FDGPET/CT显像参数进行统计学分析。结果:21例肺癌患者中,17例11C-胆碱及18FDG PET/CT显像表现为代谢增高(80.9%)。11C-胆碱PET/CT显像中病灶SUV、T/N值明显低于18FDG PET/CT显像结果(P<0.05);11C-胆碱PET/CT显像中病灶SUV、T/N值与18FDG PET/CT显像呈正相关关系(r=0.57和0.52,P=0.007和0.016);11C-胆碱PET/CT显像中SUV、T/N与病灶大小呈正相关关系(r=0.99、0.45,P=0.008 4、0.039),18FDG PET/CT显像中SUV与病灶大小呈正相关关系(r=0.68,P=0.000 7),而18FDG PET/CT显像T/N与病灶大小相关,但无统计学意义。结论:11C-胆碱反映肿瘤细胞细胞膜的合成情况,在肺癌的诊断中有一定价值。Objective ： To explore the diagnostic value of ^11C-choline PET/CT imaging for pulmonary carcinoma by comparing ^11C-choline and ^18FDG PET/CT imaging in the diagnosis of pulmonary malignant lesions. Methods： Twenty-one patients with pulmonary carcinoma were examined by ^11C-choline PET/CT and ^18FDG PET/CT imaging. The images were analyzed, SUV and T/N of the lesions calculated, and all the parameters obtained underwent statistical analysis. Results： Both ^11C-choline and ^18FDG PET/CT imaging showed an increase in tracer uptake in 17 （80.9%） of the 21 patients. SUV and T/N of the lesions were significantly lower with ^11C-choline PET/CT imaging than with ^18FDG PET/CT imaging. There was a positive correlation between the T/N ratio and SUVs of ^18FDG and ^11C-choline PET/CT imaging （r = 0.57 and 0.52 ,P = 0. 007 1 and 0. 001 6）. SUV and T/N in ^11C-choline PET/CT imaging and SUV in ^18FDG PET/CT imaging are also positively correlated with the size of the malignant lesions, but T/N of the lesions under ^18FDG PET/CT imaging showed no relationship with the size. Conclusion ： ^11C-choline PET/CT imaging, capable of reflecting synthesis of cell membrane in neoplasm, is valuable in the diagnosis of pulmonary carcinoma.

关 键 词：^11C-胆碱 ^18氟去氧葡萄糖 正电子发射型计算机断层扫描/计算机断层扫描 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]