体重指数、胃动素与慢性便秘的临床研究  

Clinical research of weight index,motilin and chronic constipation

作　　者：黄跃[1] 陈宏斌[1] 谢家泰[1] 黄淳[1] 张生君[1] 

机构地区：[1]福建医科大学附属三明第一医院消化内科,福建三明365000

出　　处：《胃肠病学和肝病学杂志》2008年第8期650-651,共2页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的 讨论体重指数、胃动素与慢性便秘之间的关系。方法 79例慢性便秘患者按体重指数分为A〈20、B20～25、C〉25三组，计算各组患者所占比例，同时检测各组患者空腹及餐后1h的血浆胃动素水平，分析它们之间的差异，并与40例健康人作对照。结果 A、B、C三组慢性便秘患者所占比例分别为53．2％、25．3％、21．5％，A组患者比例明显高于B、C组，差异有显著性（P〈0．01）。A、B、C三组患者及对照组空腹及餐后1h的胃动素水平分别为：（226±38）pg／nL、（280±47）pg／nL、（293±42）pg／nL、（346±58）pg／nL；（265±47）pg／nL、（331±43）pg／nL、（328±52）pg／nL、（427±56）pg／nL。A组低于B、C组，差异有显著性（P〈0．05），B、C组低于对照组，差异亦有显著性（P均〈0．05），B、C组之间差异无显著性（P〉0．05）。结论 低体重指数患者在慢性便秘的人群中所占比例更大，其原因可能与胃动素释放水平低下有关。Objective To discuss the relation of weight index, motilin and chronic constipation. Methods According to the weight index, seventy-nine chronic constipation sufferers were divided into A 〈 20, B 20 ～ 25, C 〉 25 three groups. The comparison of each group was computed. The levels of plasma motilin in fasting state and after meal 1 h were measured and their differences were analyzed. Forty health persons were tested as controls. Results The comparison of chronic constipation patients in groups A, B and C were 53.2% , 25.3% and 21.5%. Group A sufferer＇ s comparison was significantly higher than that of group B and C （P 〈0.01 ）. The plasma motilin of group A was significantly lower than that of group B and C （P 〈 0. 05）. The plasma motilin of group B or C was also lower than that of healthy controls （P 〈 0. 05）, and there was no difference between group B and C （P 〉 0.05）. Conclusion Low weight index sufferer＇ s comparison is greater in the crowd of chronic constipation. The reason may be the low release of the plasma motilin.

关 键 词：体重指数 胃动素 慢性便秘 

分 类 号：R574.62[医药卫生—消化系统]