多波长系数法测定散利痛片中3组分的含量  

Determination of the Contents of Three Ingredients in Saridon Tablet by Multiwavelength Coeffocient Spectrophotometers

作　　者：李艳荣[1] 胡凯 蒋晔[1] 杨莹莹[1] 

机构地区：[1]河北医科大学药学院,石家庄050017 [2]邢台市妇幼保健院,河北邢台054000

出　　处：《中国现代应用药学》2008年第4期343-345,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的建立简单快速测定散利痛片中对乙酰氨基酚、咖啡因、异丙安替比林含量的方法。方法建立多波长系数法同时测定散利痛片中对乙酰氨基酚、咖啡因、异丙安替比林3组分的含量。结果对乙酰氨基酚、咖啡因、异丙安替比林线性范围分别为4．00～14．0μg·mL^-1（r=0．9994），0．806～2．82μg·mL^-1（r=0．9993），2．40～8．40μg·mL^-1（r=0．9992），平均回收率分别为100．1％，100．4％，101．1％，RSD分别为1．4％，1．6％，1．2％（n=9）。结论本法方便、快速、准确，适用于散利痛片生产过程中的快速质量控制。OBJECTIVE To establish a method for quick determination of Paracetamol, Caffeine, Propyphenazone in Saridon tablets. METHODS A muhiwavelength coefficient method was used for simultaneously determining the contents of Paracetamol, Caffeine and Propyphenazone in Saridon tablets. RESULTS The calibrating curves of Paracetamol,Caffeine and Propyphenazone were linear in the ranges of 4.00 - 14.0 μg · mL^ - 1 （ r = 0. 999 4） ,0. 806 - 2. 82 μg· mL^ - 1 （ r = 0. 999 3 ）, 2. 40 - 8. 40 μg · mL^- 1 （ r = 0. 999 2） ,with average recoveries of 100.1%, 100.4%, 101.1%, and RSD of 1.4%, 1.6%, 1.2%, respectively. CONCLUSION The method is simple, accurate, rapid and it is suitable for the quality control of Sanidon tablets in its process of production .

关 键 词：散利痛 对乙酰氨基酚 咖啡因 异丙安替比林 多波长系数法 

分 类 号：R917.102[医药卫生—药物分析学] R971.1[医药卫生—药学]