黄体酮--平阳霉素乳剂在子宫肌瘤子宫动脉栓塞术介入治疗中的应用  

Clinical Research of Gesterol- Pingyangmycin Cream in Interventional Therapy of Hysteromyoma Uterine Artery Embolization

作　　者：唐英杰[1] 郝海庆 郝占平[1] 赵锋[1] 

机构地区：[1]河北工程大学临床医学院放射科,河北邯郸056002 [2]河北省邯郸市峰峰集团邯郸医院

出　　处：《实用放射学杂志》2008年第8期1104-1107,共4页Journal of Practical Radiology

摘　　要：目的研究黄体酮-平阳霉素乳剂在子宫肌瘤介入治疗中的临床疗效及副反应。方法随机将110例子宫肌瘤患者分为聚乙烯醇微粒和黄体酮-平阳霉素乳剂栓塞2组。采用Seldinger技术,经皮穿刺行双侧子宫动脉插管,注入黄体酮-平阳霉素乳剂或聚乙烯醇微粒阻断子宫肌瘤血供。治疗前后均用B超测量子宫肌瘤体积,并观察术后各种反应和月经量变化。结果2组患者月经量恢复正常和明显减少,总有效率为95.49%;术后3个月和6个月肌瘤体积较治疗前缩小45.81%和51.80%。与治疗前比较有显著差异(P<0.01)。2组在月经量改变和子宫肌瘤体积变化上比较无显著差异。术后发热及缺血性盆腔疼痛为2组的主要副反应,无严重并发症。结论使用黄体酮-平阳霉素乳剂栓塞子宫动脉治疗子宫肌瘤,创伤小、疗效好、副作用小。黄体酮-平阳霉素乳剂是一种经济有效的新型栓塞剂。Objective To research the clinical therapeutic effect and side effect of gesterol - pingyangmycin cream in interventional therapy of hysteromyoma. Methods 110 cases of hysteromyoma underwent interventional therapy who were divided randomly into two groups ：group A with polyvinyl alcohol particle and group B with gesterol- pingyangmycin cream . By percutaneous catheterization in bilateral uterine arteriae using the technique of Seldinger, polyvinyl alcohol particle or gesterol - pingyangmyci cream were injected to blodk up the blood supply of hysteromyoma. The volume of hysteromyomas was measured with B - mode ultrasonography prior and post - treatment. The reaction of post - treatment and the changes of menstrual blood volume were observed . Results The menstruation turned to normal and or menstrual blood volume reduced obviously in two groups , the total effective rate was 95.49% . The volume of hysteromyomas diminished to 45.81% and 51.80% in 3 and 6 months,respectively after treatment. There was significant difference between prior and post- treatment（P 〈 0.01 ） ,but there was no significant difference in the changes of menstrual blood volume and hysteromyoma volume between prior or post - treatment. The side effects were fever and ischemic cavitas pelvis pain after operation. There were not serious complications. Conclusion The interventional therapy of hysteromyomas using gesterol- pingyangmycin cream to embolism uterine artery has mini- trauma,good curative effect,few side effect. Gesterol- pingyangmycin cream is a new economical and effective embolized agent.

关 键 词：子宫肌瘤 介入放射学 子宫动脉栓塞 

分 类 号：R737.33[医药卫生—肿瘤] R815[医药卫生—临床医学]