生长抑素与大黄联合应用治疗急性重症胰腺炎疗效观察  

Comparative Study on the Therapeutic Effect of Sometostatin and Dahuang Root in Patients with Severe Acute Pancreatitis

作　　者：申方[1] 薛丽[1] 

机构地区：[1]青岛大学医学院附属医院急诊科,山东省青岛市266003

出　　处：《实用心脑肺血管病杂志》2008年第7期3-5,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨生长抑素(施他宁)联合大黄治疗重症急性胰腺炎(SAP)的效果。方法将45例SAP患者随机分为联合治疗组和对照组,观测和对比两组临床指征、实验室指标、APACHE-Ⅱ评分。结果联合治疗组腹痛缓解的时间及体温、肠鸣音、血淀粉酶恢复时间与对照组比较,差异有统计学意义(P<0.05)。两组患者入院后7d和14d,联合治疗组APACHE-Ⅱ评分与对照组比较,差异有统计学意义(P<0.05)。联合治疗组在入院7d及14d时,ALT及总胆红素水平与对照组相比,差异有统计学意义(P<0.05);在入院14d,联合治疗组肌酐和尿素氮水平与对照组比较,差异有统计学意义(P<0.05)。结论施他宁和大黄联合治疗SAP有简便、价廉、疗效确切等优点,值得临床推广应用。Objective To make a comparative study on the auxiliary therapeutic effect of Stilamin and Dahuang root in patients with severe acute pancreatitis （SAP）. Methods Forty five cases of SAP were randomly divided into Dahuang root treatment group and control group. Patients in control group received rourine treatment and patients in Dahuang root group received routine treatment plus Dahuang root therapy. The clinical and laboratory parameters A - PACHE - Ⅱ scores were determined and compared between the two groups. Results The releiving time of abdominal was significantly shorter in Dahuang root group than that in control group （ P 〈 0. 05 ）, the relcovery time of peramylasemia, hyperamylaseuria, bowel sound, body tern Perature and leukocyte count were significantly shorter than those in control group （ P 〈 0. 05 ）, the recovery times of the complication （ P 〈 0. 05 ）, APACHE - II scores were also significantly lowerr in Dahuang root group than those in control group. Conclusion Dahuang root is asimple, cheap and effectivedrug for severe acute pancreatitis, it is worthy to wide use.

关 键 词：胰腺炎 急性坏死性 生长抑素 大黄 治疗 

分 类 号：R576[医药卫生—消化系统]