不同川芎药材中川芎嗪及阿魏酸含量及指纹图谱研究  

Determination and Fingerprint Analysis of Tetramethylpyrazine and Ferulic Acid in Ligusticum chuanxiong

作　　者：朱长福[1] 石全信 严玉平[1] 刘世威 孙立亚[1] 刘芳菊[1] 同利琪[1] 

机构地区：[1]河北医科大学,河北石家庄050091 [2]石家庄乐仁堂药业有限公司,河北石家庄050051 [3]河北瑞生药业有限公司,河北石家庄050035

出　　处：《中药材》2008年第8期1113-1115,共3页Journal of Chinese Medicinal Materials

摘　　要：目的:测定不同产地不同季节的川芎药材老芎和奶芎的川芎嗪及阿魏酸的含量,并建立指纹图谱,以考察两种川芎质量。方法:采用Waters液相色谱仪测定川芎嗪及阿魏酸含量。结果:老芎的川芎嗪及阿魏酸含量高过奶芎,灌县产的老芎含量最高;不同产地的相同药材品种的指纹图谱相似度较好,而老芎和奶芎相似度较差。结论:老芎与奶芎的差别较大,不宜作为同一药材使用。Objective： To determine the contents of tetramethylpyrazine （TMP） and ferulic acid in Ligusticum chuanxiong from different producing areas and seasons. Methods：The contents of TMP and ferulic acid were determined by HPLC,and then analyzed by Chromatographic Fingerprints. Results：The contents of TMP and ferulic acid from different seasons were obviously different from each other. It was much higher in ＂laoxiong＂ than that in ＂naixiong＂. The similarity of fingerprints was high if the samples were collected from the same season,or the same areas, but not different seasons. Conclusions： The contents of TMP and ferulic acid were different from different producing areas. The evident variety of Ligustieurn chuanxiong＇s fingerprints from different collecting seasons, Laoxiong and Naixiong,was not relevant for clinical use as the same medicine.

关 键 词：川芎 奶芎 川芎嗪 阿魏酸 HPLC 指纹图谱 

分 类 号：R282.2[医药卫生—中药学]