苯巴比妥对癫患者血浆型PAF-AH酶活力的影响  

Study on the effect of phenobarbital monotherapy on the level of plasma PAF-AH in patients with epilepsy

作　　者：禇春民 张桁忠[2] 陈蓓蕾[2] 王晓铃[3] 

机构地区：[1]扬州大学医学院诊断学教研室,扬州225001 [2]江苏苏北人民医院神经内科,扬州2250013 [3]江苏苏北人民医院中心实验室,扬州225001

出　　处：《中国实用神经疾病杂志》2008年第9期33-35,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的检测苯巴比妥癫癎患者血浆型血小板活化因子乙酰水解酶(PAF-AH)活性,了解苯巴比妥抗癫癎治疗对免疫功能的影响。方法采用ELISA法测定16例单药PB抗癫癎治疗未发作EP患者,14例单药PB抗癫癎治疗发作患者及16例健康对照组的血浆型PAF-AH活性。结果癫癎未发作组、癫癎发作组和健康对照组血浆型PAF-AH活性分别为(15.91±1.59)、(17.66±1.46)(、15.52±1.18)nmol/(min.μl),发作组血浆型PAF-AH活性高于健康对照组(P<0.01),未发作组与对照组无显著差异(P>0.05)。结论单药苯巴比妥抗癫癎治疗EP患者发作后血浆型PAF-AH活性升高,可能是机体的一种自我保护措施。Objective To study the effect of phenobarbital （PB） monotherapy on immunofunctions in patients with epilepsy by measuring the level of plasma PAF-AH. Methods ELISA was used to measure the plasma PAF-AH in 16 epileptic patients without seizures, 14 patients within 72h after seizures treated with phenobarbital and 16 healthy volunteers . Results Plasma PAF-AH of three groups above were （15.91±1.59）, （17.66±1.46）, （15. 52±1.18） nmol/（min · μl） ,the plasma PAF-AH of seizures group was higher than health control group（P〈0. 01）, the plasma PAF-AH of no seizures group was equal to health control group（P〉 0.05）. Conclusion The plasma PAF-AH is higher within 72h after epileptic seizures in patients accepted phenobarbital monotherapy, it may be one of the self protection of the body.

关 键 词：苯巴比妥 癫痫 血浆型血小板活化因子乙酰水解酶 

分 类 号：R742.1[医药卫生—神经病学与精神病学]