食管鳞癌组织中hPOT1蛋白的表达及其意义  

Expression of hPOT1 in Esophageal Squamous Cell Carcinoma and Their Clinical Significance

作　　者：孙瑞清[1] 冯一中[2] 成静[3] 殷瑞根[3] 

机构地区：[1]江苏大学医学院病理学教研室,江苏镇江212013 [2]苏州大学医学部病理学教研室,江苏苏州215123 [3]江苏大学医技学院,江苏镇江212013

出　　处：《苏州大学学报（医学版）》2008年第4期579-581,共3页Suzhou University Journal of Medical Science

基　　金：江苏省教育厅自然科学基金资助项目(04KJD320047)

摘　　要：目的检测食管鳞癌组织、切缘组织及癌旁组织中hPOT1蛋白的表达水平,探讨它们之间的关系及鳞癌组织中hPOT1的表达与肿瘤临床病理学参数的关系。方法采用免疫组织化学技术检测上述组织中hPOT1蛋白的表达水平。结果82例鳞癌组织、切缘组织中,hPOT1蛋白阳性表达率分别为78.05%(64/82)、73.17%(60/82)两者相比差异无统计学意义(P>0.05),51例癌旁组织中hPOT1蛋白阳性表达率为50.98%(26/51),与鳞癌组织相比差异有高度统计学意义(P<0.01)。hPOT1蛋白的表达与患者的性别、年龄及肿瘤的大小、分化程度没有相关性(P>0.05),与肿瘤浸润深度、淋巴结转移及患者生存期密切相关,有统计学意义(P<0.05)。结论hPOT1蛋白的表达与食管鳞癌的发生、发展有密切的关系,检测hPOT1蛋白的表达对判断食管鳞癌预后有一定的指导意义。Objective To detect the expression of hPOT1 in esophageal squamous cell carcinoma tissues and surgiacal margins and their adjacent almost normal tissues, and to evaluate their clinical significance. Methods Immunohistochemical technique was used to investigate the expression of hPOT1 in those tissues mentioned. Results The positivity rate of expression of hPOT1 in esophageal squamous cell carcinoma tissues and surgiacal margians and their adjacent ahnost norreal tissues were 78.05%（64/82）,73.17%（60/82）,50.98%（26/51）,respectively The difference was significant according to statistics between the carcinoma tissues and the adjacent tissues（P〈0.01）. The expression of hPOT1 was not correlated with sex,age,tumor size, differentiation degree （P〉0.05）. The expression of hPOT1 had a significant correlation with depth of invasion, lymph node metastasis and TNM staging （P〈0.05）. Conclusion Detecting the expression of hPOT1 plays an important role in predicting the prognosis of patients with esophageal carcinoma.

关 键 词：食管鳞癌 HPOT1 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]