牛磺酸对小鼠脑提取物酶活性的影响  

Effect of Taurine on the Activities of MAO-B and AChE in the Brain of Mice

作　　者：刘刚[1] 王维治[1] 

机构地区：[1]哈尔滨医科大学附属第二医院神经科,哈尔滨150086

出　　处：《中国神经免疫学和神经病学杂志》1997年第3期156-158,共3页Chinese Journal of Neuroimmunology and Neurology

摘　　要：探讨牛磺酸（Tau）对小鼠脑提取物中单胺氧化酶-B（MAO－B）和胆碱酯酶（AChE）活性的影响。结果显示Tau以10mmol／L浓度作用时，MAO－B活性无明显变化（P＞005）；当浓度上升至20、40和80mmol／L后，MAO－B活性显著下降（P＜0．05和P＜0．01）。Tau以0．1、1．0和10mmol／L浓度作用时，AChE活性与对照组无显著差异（P＞0．05）。推测Tau可降低MAO－B的活性，从而减少脑内多巴胺（DA）的降解，但对AChE无明显影响。提示Tau有可能用于治疗某些神经系统疾病，如帕金森病和抑郁症等，并初步探讨了其可能的作用机制。The purpose of this study was to investigate the effect of Taurine (Tau) on the activities of monoamino oxidase(MAO-B) and AChE in the brain of mice. The results indicated that low dose of Tau with addition of 10 mmol/L had no effect on the activity of MAO-B, as it was no significant difference with that of NS sample. The activity of MAO-B were gradually decreased with addition of higher doses of 20 mmol/L, 40 mmol/L, and 80 mmol/L of Tau (P＜0.05 or P＜0. 01). Tau had no effect on the activity of AChE in the dose of 0. 1 mmol/L, 1. 0 mmol/L, and 10 mmol/L, respectively, which was comparable to that of NS sample (P＞0. 05). In this way, Tau could increase the level of dopamine in the brain by decreasing the activity of MAO-B, but had nothing to do with acetylcholine. Tau, as an amino acid normally presents in the living body has little side or toxic effects may well be a promising treatment of some neurological diseases, such as Parkinson disease, dementia and depression.

关 键 词：牛磺酸 单腔氧化酶-B 胆碱酯酶 氨基磺酸 

分 类 号：R977.4[医药卫生—药品]