脑再灌流对大鼠脑水肿的影响  

EFFECT OF CEREBRAL REPERFUSION ON CEREBRAL EDEMA IN RAT

作　　者：杨于嘉[1] 金立明[1] 虞佩兰[1] 唐外星 张淑安[2] 刘大冲 罗涵[3] 陈广文[3] 田鹤邨 

机构地区：[1]湖南医科大学第一附属医院儿科 [2]湖南医科大学电镜室 [3]湖南医科大学病理生理学教研室 [4]湖南医科大学蚌埠医学院

出　　处：《湖南医科大学学报》1990年第4期333-336,共4页Bulletin of Hunan Medical University

基　　金：湖南省卫生厅资助项目

摘　　要：使用大鼠4—动脉阻断模型,观察脑缺血30min,再灌15、30、60和180min各组动物脑含水量,伊文思蓝血管外渗和超微结构的改变。结果发现脑含水量增加,再灌流时较单纯缺血明显。单纯缺血和再灌流15min为细胞性脑水肿,再灌30～180min时,细胞性和血管源性脑水肿同时存在。To investigate the changes of water content of brain and ultrastructure in cerebral ischemia and reperfusion, a 4-vessel occlusion rat model of cerebral ischemia was used, and blood reperfusion was allowed by release of bilateral common carotid arteries at 30 minutes after ischemia. Compared with the normal group,the cerebral water content increased in group of reperfusion at 15 minutes (p<0. 05), 30 and 60 minutes (p<0. 01). Ultrastructurelly, cytotoxic brain edema occurred in rats of 30 minutes of cerebral ischemia and both cytotoxic and vasogenic brain edema in rats of 30,60, and 180 minutes of reperfusion after 30 minutes cerebral ischemia.

关 键 词：脑水肿 再灌流损伤 局部缺血 

分 类 号：R742.7[医药卫生—神经病学与精神病学]