VL30内源性反转录转座子的研究进展  

Advances in the Research of Endogenous Retrotransposon VL30 Elements

作　　者：高巍[1,2] 范义辉[1] 于旸[1] 白静[1] 傅松滨[1] 

机构地区：[1]哈尔滨医科大学医学遗传学研究室,150081 [2]哈尔滨医科大学国际遗传学杂志编辑部1,150081

出　　处：《国际遗传学杂志》2008年第4期307-311,共5页International Journal of Genetics

基　　金：国家自然基金（30370783）;黑龙江省教育厅振兴老工业基地重大科技与面上项目（FSB-28,10551156）

摘　　要：VL30（virus—like30S）内源性反转录转座子是近年发现的由RNA介导的转座元件，广泛分布于啮齿类基因组，也作为内源性逆转录病毒的结合部存在于人类基因组中。它与脑缺血、珠蛋白病、黑色素细胞瘤等多种疾病的发生相关。本文就VL30的结构、功能及其与一些疾病的关系作一综述，讨论其未来的发展。Endogenous retrotransposon VL30 elements discovered in recent years are a kind of trans- position elements through an RNA intemediat, which are scattered throughout the genome of rodents and also exist in humans as part of the burden of endogenous retroviruses. They are correlated to many nosogenesis, such as cerebral ischemia, globin disorders, melanocytoma. The paper reviews the structures and functional properties of VL30 elements, and its relation to some diseases, and provides a potential cue for future inves- tigation.

关 键 词：VL30 内源性 反转录转座子 小鼠 

分 类 号：S661.2[农业科学—果树学]