皮肤干细胞的定位  

Location of skin stem cells

作　　者：黄珊珊[1] 王青[1] 李利[1] 

机构地区：[1]四川大学华西医院皮肤科,四川省成都市610041

出　　处：《中国组织工程研究与临床康复》2008年第34期6723-6726,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：应用计算机检索Pubmed数据库1990～2008年、中文期刊全文数据库1998-2008年与皮肤干细胞定位相关的文献,44篇文献资料分析结果显示,毛囊bulge区细胞具有高度增殖潜能,为标记滞留细胞,具有多向分化潜能,不表达分化细胞特异性标志,表达干细胞标志,为目前公认的表皮干细胞的定居处。毛囊真皮鞘包含具有可塑性的干细胞,认为是真皮干细胞的定居处。毛囊真皮乳头内含有具一定增殖分化能力的前体细胞,与真皮鞘相互作用,能够诱导毛囊形成,目前观点认为,真皮乳头内前体细胞移行自真皮鞘干细胞,为其活化的子代细胞。毛囊间皮肤与无毛区皮肤是否存在皮肤干细胞尚存争论,部分实验表明,毛囊间表皮基底层亦有表皮干细胞的存在。Pubmed （1990-2008） and China Journal Full-text Database （CJFD） （1998-2008） were searched for relevant articles on localization of skin stem cells. A total of 44 articles revealed that hair follicle bulge cells that are label-retaining cells regenerate themselves by division and can give rise to differentiated progeny. They did not express characteristic markers of differentiated cells, but stem cells markers. Therefore hair follicle bulge region was considered to be epidermal stem cells niche. Hair follicle dermal sheath housed multipotent and plastic stem cells, considered to be dermal stem cells niche. Hair follicle dermal papilla interacted with dermal sheath to induce the formation of hair follicle. It is believed that precursor cells in dermal papilla harvested from dermal sheath stem cells are the active daughter cells. Whether skin stem cells are present in hair follicle and hairless region is under debate. Some studies found that skin stem cells were detected in the basal layer of epidermis in hair follicle.

关 键 词：表皮干细胞 真皮干细胞 定位 

分 类 号：R394.2[医药卫生—医学遗传学]