piRNA:一类新的非编码小RNA  

Piwi-interacting RNA(piRNA):a Novel Class of Noncoding Small RNA

作　　者：黄雪梅[1] 张守涛[1] 王芳[1] 刘伟[1] 张一折[1] 

机构地区：[1]郑州大学生物工程系,郑州450001

出　　处：《中国生物工程杂志》2008年第8期130-135,共6页China Biotechnology

基　　金：国家自然科学基金(30700067)资助项目

摘　　要：piRNA(Piwi-interacting RNA)是从哺乳动物生殖细胞中分离得到的一类长度约为30nt的小RNA,并且这种小RNA与PIWI蛋白家族成员相结合才能发挥它的调控作用。目前,越来越多的文献表明piRNA在生殖细胞的生长发育中的调控是由于Piwi-piRNA复合物引起的基因沉默导致的,但由于对piRNA的研究尚处于初级阶段,它的一些具体的功能和生源论尚在研究当中。综述了piRNA的最新研究进展。piRNA （Piwi-interacting RNA） is a novel class of small single strand RNA that were recently isolated from testes of the mammals, associate with PIWI proteins, and are organized into distinct genomic clusters. These RNAs are typically 30 nt long, strikingly different from microRNAs in their length, expression pattern, and genomic organization, piRNA has a role in RNA silencing via the formation of an RNA-induced silencing complex （RISC） with Piwi proteins, these piRNA complexes （piRCs） have been linked to transcriptional gene silencing of retrotransposons and other genetic elements in germ line cells, particularly those in spermatogenesis. Recent researches and progresses of piRNAs are reviewed.

关 键 词：PIRNA 非编码 小RNA 生殖细胞 发育 

分 类 号：Q74[生物学—分子生物学]