胰腺癌伴随炎症的病理学研究  

CLINICOPATHOLOGICAL FEATURES OF INFLAMMATION IN PANCREATIC ADENOCARCINOMA

作　　者：王玉兰[1] 韦立新[1] 顾倬云[1] 宋欣[1] 

机构地区：[1]解放军总医院,北京100853

出　　处：《肝胆外科杂志》2008年第4期266-269,共4页Journal of Hepatobiliary Surgery

摘　　要：目的探讨胰腺癌的炎症病理学特征。方法对76例胰腺腺癌病例的临床资料、HE特点及免疫组化特征进行分析,并复习文献。结果76例胰腺腺癌,有85.53%(65/76)在肿瘤组织中、肿瘤周边及较远胰腺组织中有不同程度的炎细胞浸润,以淋巴细胞、中性粒细胞及组织细胞为主,浆细胞也常常能看到。有93.42%(71/76)肿瘤周边及61.84%(47/76)远处胰腺组织中有不同程度的纤维化。有25.00%(19/76)能看到脂肪坏死。免疫组化显示在肿瘤中浸润的淋巴细胞为T淋巴细胞和B淋巴细胞,而在肿瘤周边以T淋巴细胞为主。结论胰腺癌伴随炎症是一种常见的病理现象,浸润炎细胞以淋巴细胞、中性粒细胞及组织细胞为主,其炎症特征与其生物学行为及术后并发症可能有关。Obstract To characterize the inflammatory infiltrate in pancreatic adenocarnoma. Methods 76 pancreatic ductal adenocarnoma cases were analyzed by HE and immunohistochemical staining, and the related literature reviewed. Results There were significantly lymphocytes , neutrophilic leukocytes and macrophages in 85.53% （65/76） pancreatic cancers, and plasma ceils were also ofen exist. There were different dense of fibres stroma around the tumor 93.42% （71/76） and in the faror pancreatic tissues 61.84% （47/76） . fat necrosis were seen in 25.00% （19/76） cases. Inmmunostaining revealed T lymphcytes and B lymphcytes infiltrated in- tratumors, and only T lymphcytes infiltrated around the tumor tissues. Conclusions pancreatic adenocarcinoma is characterized by a dense , desmoplastic stroma rich in collagen fibres, fibroblasts, and inflammatory cells. The inflammatory cells inclouds lymphocytes, neutrophilix leukocytes and macrophages. And the inflammatory characteration may influence it＇s biological behaviour and the complication.

关 键 词：胰腺腺癌 炎症 病理学分析 胰腺 

分 类 号：R735.9[医药卫生—肿瘤]