伴有颈动脉粥样硬化的急性脑梗死与胰岛素抵抗关系的临床研究  

Relationship between acute carotid cerebral infarction and insulin resistance

作　　者：姜丽杰[1] 高政[1] 孙文芳[1] 宋妮娜[1] 

机构地区：[1]大连医科大学附属二院北院神经内科,116031

出　　处：《中国临床实用医学》2008年第8期22-24,共3页China Clinical Practical Medicine

摘　　要：目的探讨在伴有颈动脉粥样硬化（CAS）的急性脑梗死的发病机制中胰岛素抵抗（IR）的作用及二者之间的关系。方法选择急性脑梗死患者84例，并分为：有CAS组44例，无CAS组40例；比较两组之间空腹血糖（FPG）、胰岛素抵抗指数（HOMA—IR）等13个因素中是否存在差异；并了解伴有CAS的急性脑梗死与上述各因素之间的关系。结果有CAS组FPG、FINS、HOMA—IR、TC、TG、LDL、UA、FIB明显高于无CAS组；ISI明显低于无CAS组，P〈0．01或P〈0．05；LDL、HOMA—IR、FINS、TG为伴有CAS的急性脑梗死发生的危险因素。结论IR是伴有CAS的急性脑梗死的危险因素之一。Objective To evaluate the effects of insulin resistance（IR） in acute carotid atherothrombotic cerebral infarction and the relationship between them. Methods 84 patients diagnosed with acute cerebral infarction were chosen, being divided with carotid atherosclerosis （CAS） and 40 without CAS. Compared the differences of FPG, HOMA-IR et al. in acute cerebral infarction with and without CAS, and the relationship with CAS. Results There were significant differences in FPG, FINS, HOMA-IR, ISI, FIB, TC, TG, LDL, UA between acute carotid atherothrombotic cerebral infarction and that of without CAS （ P 〈 0. 01 or P 〈 0. 05 ）. LDL, HOMA- IR, FINS and TG are the risk factors of acute carotid atherothrombotic cerebral infarction. Conclusion IR is one of the risk factors of acute carotid atherothrombotic cerebral infarction.

关 键 词：急性脑梗死 颈动脉粥样硬化 胰岛素抵抗 

分 类 号：R743[医药卫生—神经病学与精神病学] R587[医药卫生—临床医学]