大蒜素自微乳肠溶制剂的体外评价  

In vitro evaluation of self-microemulsifying enteric-coated preparations containing garlicin

作　　者：胡玉熙[1] 刘清飞[1] 陈曦[1] 王义明[1] 罗国安[1] 

机构地区：[1]清华大学生命科学与医学研究院

出　　处：《中国新药杂志》2008年第15期1331-1335,共5页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(30500666)

摘　　要：目的:对大蒜素自微乳肠溶软胶囊、肠溶液体硬胶囊进行体外评价。方法:对该2制剂进行自微乳化效率、粒径、形态等理化性质的考察和含量的测定,比较2制剂与市售制剂在不同释放条件下的释放度。结果:自微乳化效率<1 m in,2制剂经分散后可得到平均粒径均在(30±2)nm、呈高斯分布的球形微乳,2制剂释放度分别为80.8%和81.5%,明显高于市售制剂。结论:自微乳肠溶制剂显著提高了大蒜素的体外溶出。Objective：In order to increase the delivery degree of the garlicin enteric-coated preparations,the self-microemulsifying enteric-coated soft-capsule and enteric-coated liquid capsule of garlicin were prepared and their characteristics in vitro were evaluated. Methods：The physic-chemical property such as the self-microemulsifying efficiency,droplet size, appearance, and the contents of both preparations were investigated. The different release property of both preparations and conventional enteric-coated soft capsule under different condition were compared. Results：The two formulations showed good self-microemulsifying efficiency with less than one minute and stabilities. The particle size was （30 ± 2） nm with Gaussian distribution. The release degree of the formulations in vitro respectively were 80.8% and 81.5% ,which were obviously higher than that of the conventional soft capsules. Conclusion：The SMEDDS of the enteric-coated preparations can increase release of garlicin in vitro.

关 键 词：微乳 自微乳释药系统 大蒜素 软胶囊 液体硬胶囊 

分 类 号：R943.41[医药卫生—药剂学]