非酒精性脂肪肝和心血管疾病  

Non-alcoholic fatty liver disease and cardiovascular disease

作　　者：丁佳[1] 范竹萍[1] 

机构地区：[1]上海交通大学医学院附属仁济医院消化科上海市消化疾病研究所,200001

出　　处：《国际消化病杂志》2008年第4期320-322,共3页International Journal of Digestive Diseases

摘　　要：非酒精性脂肪肝(NAFLD)是临床慢性肝脏疾病,包括单纯的肝细胞脂肪变、脂肪性肝炎(NASH)、肝脏纤维化甚至肝硬化等,是临床隐原性肝硬化最常见的病因。胰岛素抵抗(IR)和中央性肥胖是NAFLD的重要发病机制。同时由中央性肥胖、2型糖尿病、胰岛素抵抗、高血压及血脂异常等组成的代谢综合征(MS)是心血管疾病(CVD)的高危险因素。现在,越来越多的研究认为NAFLD是MS在肝脏系统的表现,NAFLD的出现可能不仅仅是CVD发生的标志,甚至是CVD的早期中间状态。Non-alcoholic fatty liver disease （NAFLD） comprises a wide spectrum of liver damage ranging from simple, uncomplicated steatosis to steatohepatitis to advanced fibrosis and cirrhosis, which mostly attributes to cryptogenic cirrhosis. Insulin resistance and truncal obesity play a critical role in the pathogenesis of NAFLD. Abdominal obesity, type 2 diabetes, insulin resistance, hypertension and dyslipidaemia-the typical components of the metabolic syndrome （MS） are risk factors for cardiovascular disease （CVD）. Nowadays, more and more study supports the notion that NAFLD may be the hepatic manifestation of the MS. Therefore, NAFLD as a component of the MS, might not only be a marker but also an early mediator of CVD.

关 键 词：非酒精性脂肪肝 心血管疾病 胰岛素抵抗 中央性肥胖 

分 类 号：R575.5[医药卫生—消化系统] R54[医药卫生—内科学]