精神分裂症患者认知功能评价及其与精神症状的相关性  

Evaluation of Cognitive Functions and Its Corelation with Psychiatric Symptoms in Patients with Schizophrenia

作　　者：王雪[1] 任艳萍[1] 贺佳丽[1] 周东丰[2] 

机构地区：[1]首都医科大学附属北京安定医院 [2]北京大学第六医院

出　　处：《首都医科大学学报》2008年第4期423-427,共5页Journal of Capital Medical University

基　　金：北京市科委基金(2003BA712A11-04)资助项目~~

摘　　要：目的探讨精神分裂症患者的认知功能及其与精神症状的相关性。方法入组31例精神分裂症患者及31例正常对照者,进行持续操作测验(CPT)、威斯康星卡片分类测验(WSCT)、Stroop色词测验、可反复测查的成套神经心理状态评估工具(RBANS)以及阳性与阴性症状量表(PANSS)评定,对心理测查成绩与精神症状指征进行相关性分析。结果精神分裂症患者组与正常对照组相比,除Stroop色词测验中卡片A(字)、B(色)、C(字色)错误数无明显差异外,各项心理测查指标均明显下降(P<0.05)。多项心理测查成绩,包括CPT测验中正确反应时、WSCT测验中随机错误数、Stroop色词测验中字义干扰时和颜色干扰时、RBANS测验总分和即刻记忆分,与PANSS部分症状评分显著相关(P<0.05)。结论精神分裂症患者记忆、注意、执行及言语功能受损。精神分裂症患者部分认知功能与精神症状显著相关。Objective To evaluate the cognitive function and its correlation with psychiatric symptoms in patients with schizophrenia. Methods Thirty-one patients with schizophrenia and thirty-one healthy person as control were evaluated by neuropsychological test, such as continuous performance test （ CPT）, wisconsin card sorting test （WSCT） , stroop color-word test and repeatable battery for the assessment of neuropsychological status（RBANS） , and the positive and negative syndrome scale（PANSS） in schizophrenic patients. Results The scores in all items of neuropsychological test except the A, B, C wrong numbers of Stroop color- word test in schizophrenic patients were significantly poorer than those in healthy controls （ P 〈 0.05 ）. The correct time in CPT, the random wrong number in WSCT, word interference time and color interference time in Stroop color-word test, immediate memory score and total score in RBANS were significantly correlated with part of the scores in PANSS（P 〈 0.05）. Conclusion The memory, attention, executive performance and verbal function were impaired, and some cognitive function scores were significantly correlated with the psychiatric symptoms in patients with schizophrenia.

关 键 词：精神分裂症 认知功能 精神症状 

分 类 号：R749.3[医药卫生—神经病学与精神病学]