血清孕酮含量与前部缺血性视神经病变的相关性研究  

Correlation research on progesterone concentration in serum and anterior ischemic optic neuropathy

作　　者：李晓娟[1] 朱晓谦[2] 吴静[3] 李东亮[1] 

机构地区：[1]新乡医学院生理学与神经生物学教研室,河南省新乡市453003 [2]新乡医学院第三附属医院眼科,河南省新乡市453003 [3]暨南大学医学院眼科,广东省广州市510632

出　　处：《眼科新进展》2008年第9期674-675,共2页Recent Advances in Ophthalmology

基　　金：新乡市科委立项课题基金资助(编号:07S051)~~

摘　　要：目的通过检测血清孕酮含量,了解孕酮与前部缺血性视神经病变发病的相关性。方法收集前部缺血性视神经病变患者32例32眼为病变组,选取同期非缺血性视神经病变患者30例30眼为对照组。ELISA方法检测2组患者血清孕酮的含量,并进行统计学分析。结果病变组血清孕酮的含量为(0.41±0.15)μg.L-1,明显低于正常对照组(1.13±0.12)μg.L-1,差异有统计学意义(P<0.05)。病变组血清孕酮含量与视力的相关分析示,2者正相关(r=0.808,P<0.05),表明血清孕酮含量越低,视力损害越重。结论前部缺血性视神经病变患者血清中孕酮含量减少,对视神经的保护作用减弱,可能是缺血性视神经病变的主要发病机制之一。Objective To detect the concentration of progesterone in serum and study its correlation with anterior ischemic optic neuropathy. Methods The serum of 32 eyes of 32 normal control people and 30 eyes of 30 patients with anterior ischemic optic neuropathy were collected and detected with fluorescein fundus angtography. The concentration of progesterone of both two groups were measured with ELISA method,and analyzed statistically. Results The concentration of progesterone in patient with anterior ischemic optic neuropathy[ （ 0.41 ± 0.15 ） μg · L^-1] was significant lower than that in control group [ （ 1. 13 ± 0. 12） μg · L^-1 ] ,and showed significant difference（ P 〈 0. 05 ）. The relative coefficient between visual acuity and the concentration of progesterone in patient group showed these two positive correlated （r = 0. 808, P 〈 0. 05 ）. The lower was the concentration of progesterone in serum, the worse the vision of the patients was. Conclusion The decreasing of progesterone concentration in serum may result in the attenuating of the protection, which is probably the main pathogenesis for anterior ischemic optic neuropathy.

关 键 词：孕酮 前部缺血性视神经病变 ELISA法 

分 类 号：R774.6[医药卫生—眼科]