精神活性物质与DNA甲基化  

Psychoactive substances and DNA methylation

作　　者：文睿婷[1] 梁建辉[1] 

机构地区：[1]北京大学中国药物依赖研究所,北京100083

出　　处：《中国药理学通报》2008年第8期996-999,共4页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展计划(973计划)资助项目(No2003CB515400);国家自然科学基金资助项目(No30570653);教育部985资助项目(北京大学天然药物及仿生药物国家重点实验室)

摘　　要：精神活性物质滥用能引起神经细胞特定的适应性反应,从而导致依赖。同时,滥用物质本身对机体细胞也可表现出一定的毒性损伤作用。研究表明:DNA甲基化作为一种重要的表观遗传修饰作用,其对基因表达的调控可能是导致这种适应性反应及毒性损伤的重要机制之一。该文介绍了DNA甲基化的分子机制及影响因素,并以酒精、甲基苯丙胺、吗啡、可卡因为例,阐述了精神活性物质的药理学及毒理学作用与DNA甲基化之间的密切关系。Psychoactive substances abusing may induce neuron- specific adaptation and lead to physical and psychological de- pendence. Moreover, psychoactive substances have toxicological actions to cause physical damages. It has been reported that DNA methylation,acting as an epigenetic modification, may be one of the mechanisms involved in these adaptive changes and physical damages. This review shows a general introduction to the molecular mechanism of DNA methylation, and expounds the pharmacological and toxicological effects of some psychoactive substances on DNA methylation, including ethanol, methamphetamine, morphine, and cocaine.

关 键 词：DNA甲基化 精神活性物质 依赖 躯体损伤 

分 类 号：R-05[医药卫生] R394