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作 者:许国强[1] 胡凤玲[1] 金恩芸[1] 徐根云[1] 陈洪潭[1] 单国栋[1] 杨铭[1] 吴益群[1]
机构地区:[1]浙江大学医学院附属第一医院,浙江杭州310003
出 处:《浙江预防医学》2008年第9期2-4,共3页Zhejiang Journal of Preventive Medicine
基 金:浙江省科技计划项目(2005C30027)
摘 要:目的探讨胆囊结石患者的血清瘦素(leptin)和血脂水平与胆囊结石形成的关系及其临床意义。方法采用放射免疫法等测定胆囊结石组及正常对照组的血清leptin、血脂水平,比较分析2组间leptin、血脂的水平以及不同性别间的leptin、血脂水平的差异。结果胆囊结石组血清leptin水平高于正常对照组,其中男性胆囊结石患者的血清leptin水平显著高于正常对照组。胆囊结石组血清甘油三酯(TG),总胆固醇(TCH)水平显著高于正常对照组;而血清高密度脂蛋白(HDL)水平则显著低于正常对照组。结论胆囊结石患者血清leptin、TG、TCH升高,HDL水平降低,这些变化可能与胆囊结石的形成有关。Objective To investigate the relationship between and the clinical significance of the characteristics of serum leptin and lipids levels in patients with gallbladder gallstone and gallstone formation. Methods 156 patients with gallbladder gallstone were selected as ease group and 52 healthy people as control group. Radioimmunoassay and other methods were used to measure the levels of serum lepfin and lipids, and then statistical methods were used to analyze the differences. Results Serum leptin, trigtyeeride (TG) and total eholesterel (TCH) levels in ease group were higher that in control group, but serum high density lipoprotein (HDL) level was significantly lower. Serum leptin in male patients with gallbladder gallstone was significantly higher than that in control group. Conclusion The variations of serum leptin, TG, TCH, HDL levels in patients with gallbladder gallstone may be related to the formation of gallbladder gallstone.
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