CT导引下^(125)Ⅰ粒子组织间置入治疗恶性骨肿瘤  

CT-guided Iodine-125 Implantation in the Treatment of Malignant Osseous Tumor

作　　者：高斌[1] 贺克武[1] 李劲松[1] 巢惠民[1] 胡永胜[1] 黄永翠[1] 

机构地区：[1]安徽省合肥市第一人民医院影像中心,230061

出　　处：《临床放射学杂志》2008年第8期1107-1110,共4页Journal of Clinical Radiology

基　　金：合肥市重点科研立项项目(编号:2006004)

摘　　要：目的探讨125I粒子组织间置入在恶性骨肿瘤中的治疗价值。资料与方法在CT导引下对19例25个恶性骨肿瘤病灶进行125I粒子组织间置入术,术后观察患者病灶影像学变化及疼痛缓解情况。结果125I粒子组织间置入治疗恶性骨肿瘤疼痛缓解有效率为94.7%(18/19),术后1、2及6个月病灶影像学观察结果显示25个恶性骨肿瘤病灶中,明显缓解(OR)2个,部分缓解(PR)15个,轻度缓解(SD)7个,无效(PD)1个,总缓解率(OR+PR)为68%。所有患者均未出现严重不良反应。结论CT导引下125I粒子组织间置入治疗恶性骨肿瘤是一种安全、有效、微创的治疗方法,值得进一步在临床推广应用。Objective To evaluate the curative value of CT guided iodine 125（^125I） implantation for malignant osseous tumors. Materials and Methods Under CT guidance, ^125I seeds were implanted into 25 malignant osseous tumor lesions of nineteen patients. The curative effect was evaluated according to the change in the radiology imaging and the ostealgia relief. Results After treated with iodine 125（^125I） implantation, 17cases among 19 cases relieved from pain. The effective rate was 89.5%. Follow up CT examinations in 1,2 and 6 months demonstrated that 25 lesions,2 obtained OR, 15 obtained PR,7 SD and 1 PD. The responsive rate was 68%. Severe side effect did not occure in these cases. Conclusion CT guided ^125I implantation is safe ,available and feasible for malignant osseous tumor,it is worthy to be further widely used in clinic.

关 键 词：骨 肿瘤 近距离放射疗法 碘放射性同位素 

分 类 号：R738.1[医药卫生—肿瘤] R657.405[医药卫生—临床医学]