普罗布考对脑梗死患者急性期血清oxLDL-Ab水平的影响  

Effect of Probucol on the Level of oxLDL-Ab in Acute Stage of Cerebral Infarction

作　　者：刘启兵[1] 张兆辉[2] 

机构地区：[1]咸宁学院医学院,湖北咸宁437100 [2]武汉大学人民医院神经内科

出　　处：《咸宁学院学报（医学版）》2008年第3期198-200,共3页Journal of Xianning Univarsity(medical Sciences)

摘　　要：目的观察普罗布考对脑梗死患者急性期血清氧化型低密度脂蛋白自身抗体(oxLDL-Ab)水平的影响。方法采用自身对照和组间对照,将62例急性期脑梗死患者分为两组,其中普罗布考组(32例),常规组(30例)。用酶联免疫吸附法测定治疗前后血清oxLDL-Ab水平的变化。以神经功能评分为标准,分别观察治疗7d和14d后两组的疗效。结果①普罗布考组治疗2周后,血清oxLDL-Ab水平较治疗前明显降低(P<0.05),神经功能明显改善(P<0.05)。②治疗2周后,普罗布考组血清oxLDL-Ab水平均较常规组明显降低(P<0.05),神经功能明显改善(P<0.05)。③两组治疗前,血清oxLDL-Ab与LDL水平均具有相关性(P<0.05)。结论普罗布考能降低脑梗死患者急性期血清oxLDL-Ab水平,通过稳定动脉粥样硬化斑块,减轻缺血性脑损伤,提高患者的近期疗效。Objective To observe the effect of probucol on the level of oxLDL-Ab in acute stage of cerebral infarction. Methods Using random and single blind contrast, 62 patients with cerebral infarction in acute stage were devided into probucol, group （ n = 32） and convention group （ n = 30）. With the method of ELISA, the level of oxLDL-Ab in serum was measured before and after therapy. At 7 d and 14 d, to observe curative effect by standard scale of clinical neurological deficit. Results ①After 2 weeks of follow-up, the level of oxLDL-Ab in serum was obviously decreased（P 〈0.05 ） and the neurological function was improved（ P〈0.05 ） in the probucol group. ②The level of oxLDL-Ab in serum was obviously decreased （P 〈 0.05 ） and the neurological function was improved（P 〈 0.05 ）in the probucol group compared with the convention group after two- week therapy. ③The level of oxLDL-Ab was depended on the level of LDL before therapy in the two groups （ P 〈 0.05）. Conclusion Probucol can reduce the level of oxLDL-Ab in acute stage of cerebral infarction, probably,stabilize atherosclerotic plaque and relieve the ischemic brain injury to improve curative effect.

关 键 词：普罗布考 脑梗死 氧化低密度脂蛋白自身抗体 

分 类 号：R743.3[医药卫生—神经病学与精神病学]