具有基底细胞样表型的乳腺化生性癌  

Clinicopathological analysis of metaplastic breast carcinomas with basal-like phenotype

作　　者：邵牧民[1] 徐华[1] 何沁[1] 余学问[1] 

机构地区：[1]广东省深圳市中医院病理科,广东深圳518033

出　　处：《安徽医药》2008年第10期921-923,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨具有基底细胞样表型的乳腺化生性癌的临床病理特征和免疫表型特点。方法观察分析3例具有基底细胞样表型的化生性乳腺癌的病理组织学特征,并利用EnVision法进行免疫组化标记检测ER、PR、CerbB-2、CD10、SMA、p63、CK5/6、CK14、EGFR蛋白的表达。结果组织学类型分别为梭形细胞化生性癌、腺鳞癌(浸润型)、腺鳞癌(囊内型)。组织学特征表现为乳腺癌伴有梭形细胞化生或鳞状上皮化生,细胞较大,部分异型性较明显,多伴有坏死,核分裂象常见;有囊腔形成及导管内上皮内肿瘤成分。免疫组化结果:CK5/6、CK14、p63、p53均阳性表达;EGFR 2例阳性表达;E-Cadherin 2例阳性表达;1例PR20%阳性表达,其余2例均不表达;ER、CerbB-2、CD10、SMA均不表达。结论乳腺化生性癌具有基底细胞样型乳腺癌特有的免疫表型特征,其临床预后宜参照基底细胞样型乳腺癌。Aim To investigate the clinicopathological and immunohistochemical characteristics of metaplastic breast carcinomas with basal-like phenotype. Methods Three cases of metaplastic breast carcinomas were studied with clinicopathological observation and immunohistoehemical analysis. Results Microscopically, the tumors had the characteristics of breast carcinomas with spindle cell or squamas differentiation. The tumor cells were biger, many of which had apparente heteromorphism, the necrosis and the mitotic figure was easily seen. The component of capsular space or ductal carcinoma in situ was usually found. Immunohistochemically, the tumor cells were positive for CK5/6 ,CK14 ,p63 and p53. The tumor cells of 2cases were positive for EGFR, And the tumor cells of 2cases were positive for E- Cadherin. Coneluslon The metaplastic breast carcinomas have the clinicopathological and immunohistochemical characteristics of basal- like subtype of breast carcinoma. This can be regarded as basal-like subtype of breast carcinoma in treatment and follow-up.

关 键 词：乳腺 化生眭癌 基底细胞样癌 病理 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤] R733.71[医药卫生—临床医学]