牛磺酸通过ERK1／2信号途径促进成骨细胞分化  

Taurine stimulates osteoblast differentiation via ERK1/2 signal pathway

作　　者：卢瑛[1] 袁凌青[1] 谢辉[1] 罗湘杭[1] 伍贤平[1] 周厚德[1] 廖二元[1] 

机构地区：[1]中南大学湘雅二医院代谢内分泌研究所,长沙410011

出　　处：《中华内分泌代谢杂志》2008年第4期387-388,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：牛磺酸（taurine）增强成骨样MG63细胞碱性磷酸酶活性，促进骨钙素的分泌和矿化结节的形成。细胞信号转导研究发现牛磺酸诱导成骨细胞细胞外信号调节激酶1／2（ERK1／2）磷酸化，ERK1／2抑制剂PD98059可阻断牛磺酸对成骨细胞的促分化作用。提示牛磺酸通过ERK1／2信号转导途径促进成骨样MG63细胞的分化。This in vitro study demonstrated that taurine supplemented culture medium enhanced alkaline phosphatase （ALP） activity, osteocalcin secretion and mineralized matrix formation. Taurine induced activation of ERK1/2 and osteoblast differentiation, which was blocked by pretreatment of osteoblasts with ERK1/2 inhibitor （PD98059）, suggesting taurine stimulated osteoblast differentiation via ERK1/2.

关 键 词：牛磺酸 碱性磷酸酶 骨钙素 成骨细胞 丝裂原活化蛋白激酶 

分 类 号：R580[医药卫生—内分泌]