保元胶囊治疗慢性肾小球肾炎的临床研究  

Clinical study of Baoyuan capsule on treating chronic glomerulonephritis

作　　者：闫慧明[1] 李青[1] 张国瑛[1] 魏华娟[1] 彭云松[1] 

机构地区：[1]河北省石家庄市中医院肾内科,河北石家庄050051

出　　处：《河北中医》2008年第9期904-906,共3页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省科学技术研究与发展计划项目(编号:07276101D-24)

摘　　要：目的观察保元胶囊治疗慢性肾小球肾炎的临床疗效。方法慢性肾小球肾炎98例,随机分为2组,治疗组48例予保元胶囊,每次5粒,每日3次口服。对照组50例予盐酸贝那普利片,每次10 mg,每日2次口服。2组均3个月为1个疗程。观察治疗前后血浆白蛋白、总蛋白、24 h尿蛋白定量、免疫球蛋白(Ig)和补体3(C3)、肾功能指标以及血压的变化。结果①2组24 h尿蛋白定量治疗后较治疗前均明显下降(P<0.05),但2组治疗后比较差异无统计学意义(P>0.05);②2组血浆白蛋白、总蛋白治疗后较治疗前均明显升高(P<0.05),但仅血浆白蛋白治疗后比较差异有统计学意义(P<0.05);③治疗组C3I、gG水平治疗后较治疗前明显提高(P<0.05),IgA水平较治疗前明显下降(P<0.05),与对照组比较差异有统计学意义(P<0.05);④治疗组治疗后血肌酐(Cr)、尿素氮(BUN)明显下降(P<0.01),内生肌酐清除率(Cr)恢复(P<0.05),与对照组治疗后比较差异均有统计学意义(P<0.05);⑤治疗组治疗后平均动脉压(MAP)无明显变化(P>0.05)。结论保元胶囊可明显降低慢性肾小球肾炎患者尿蛋白,升高血浆白蛋白,改善免疫和肾功能,但对血压无明显影响。Objective To investigate the effect of Baoyuan capsule on treating chronic glomendonephrites. Methods 98 patients with chronic glomendonephrites were randomly divided into two groups. The patients in treatment group （ n = 48） was given Baoyuan capsule and the patients in control group （ n = 50） was given Benazepril for 3 months. The plasma albumin, total protein, the urine protein of 24 hours, immunoglobulin, complement 3 （C3）, indexes of renal function and blood pressure were observed before and after treatment. Result The urine protein of 24 hours after treatment obviously decreased in comparison with those before treatment in two groups （ P 〈 0.05）. There was no difference between two group on the level of urine protein of 24 hours after treatment （ P 〉 0.05）. The plasma albumin and total protein after treatment obviously increased in comparison with those before treatment in two groups （ P 〈 0.05）. There was significant difference between two groups only the level of plasma albumin after treatment （ P 〈 0.05）. C3 and IgG after treatment obviously increased in comparison with those before treatment in treatment group （ P 〈 0.05）. Serum creatinine and urea nitrogen after treatment obviously decreased in comparison with those before treatment in treatment group （ P 〈 0.01 ）. Mean arterial pressure after treatment didn＇ t obviously change I comparison with before treatment （ P 〉 0.05）. Conclusion Baoyuan capsule had certain effects on chronic glomendonephrites, by decreasing proteinuria, increasing plasma albumin in serum of patients. And Baoyuan capsule can improve immtmifaction and renal function.

关 键 词：胶囊 慢性病 肾小球肾炎 中药疗法 

分 类 号：R36[医药卫生—病理学] R692.310.531[医药卫生—基础医学]