莫沙必利治疗功能性消化不良的临床研究  

A Clinical Study on the Effect of Mosapride on Functional Dyspepsia

作　　者：曹大春[1] 黄欣[1] 张哲永[1] 

机构地区：[1]上海交通大学医学院附属人民医院消化科,上海200011

出　　处：《临床消化病杂志》2008年第4期223-224,共2页Chinese Journal of Clinical Gastroenterology

摘　　要：目的探讨莫沙必利对功能性消化不良患者的疗效。方法符合功能性胃肠病罗马Ⅱ诊断标准的FD患者84例,随机接受莫沙必利5mg,每天3次(A组,42例)或吗丁啉5mg,每天3次(B组,42例),记录治疗前及治疗后患者症状积分和钡条胃排空数。结果A组患者有效率为85.71%,B组为66.67%,两组间差异有统计学意义(P<0.01)。胃排空钡条数在治疗前均明显少于正常对照组(P<0.01),治疗后2组明显增多(P<0.05),两组差异显著(P<0.05)。结论莫沙必利治疗功能性消化不良的效果优于吗丁啉。Objective To investigate the clinical effect of mosapride in treating functional dyspepsia（FD）. Methods Eighty-four patients meeting Rome Ⅱ criterion were randomly received either mosapride 5mg rid（ group, A 42 patients）or domperidone 5mg rid （group, B 42 patients） for 4 weeks. The symptoms were evaluated before treatment and at the end of 4th week. Gastric emptying of solid food was examined by using radiopaque markers in twelve patitens from group A and group B, respectively. Results The clinical curative rates were 85.71% in group A and 66.67% in group B. There was significant difference between two groups（ P 〈0. 05）. After the treatment the average number of barium strip expelled from stomach were 4 in group A and 3 in group B before treatment and was significantly increased to 18 and 12（ P 〈 0. 01 ） ,respectively. Conclusion Mosapride has better clinical effect than domperidone on the treatment of FD.

关 键 词：功能性消化不良 莫沙必利 吗丁啉 

分 类 号：R57[医药卫生—消化系统]