胃癌患者血清MMP-3水平的临床研究  

Clinic study on serum MMP-3 levels in patients with gastric carcinoma

作　　者：周文鹏[1] 樊青霞[1] 范魁生[1] 王瑞林[1] 吴金民[2] 

机构地区：[1]河南省郑州大学医学院第一附属医院肿瘤科,450052 [2]浙江大学医学院附属邵逸夫医院肿瘤中心

出　　处：《中国实用医药》2008年第24期44-46,共3页China Practical Medicine

摘　　要：目的探讨胃癌患者血清MMP-3水平及其临床意义。方法应用ELISA法,对56例胃癌患者血清MMP-3水平进行测定,并同期检测56名健康人血清水平作为对照。结果胃癌患者血清MMP-3水平明显高于正常人,MMP-3水平与胃癌肿瘤大小、血管侵犯、淋巴结受累及肝脏转移密切相关(P<0.05);随着临床病理分期的升高,MMP-3水平亦明显升高(P<0.05),血清MMP-3水平与组织学类型及患者的性别和年龄等因素无关(P>0.05)。结论MMP-3参与胃癌浸润和转移,术前检测血清MMP-3水平对预测胃癌侵袭和转移具有重要的临床意义。Objective In this study,we measured the serum MMP-3 levels in patients with gastric carcinoma and evaluate its clinic significance. Methods ELISA was used to detect serum MMP-3 levels preoperatively in 56 patients with resection of gastric carcinoma and 56 healthy subjects. Results Serum MMP-3 was found to be significantly elevated in patients with gastric carcinoma, compared with healthy subjects （P 〈 0. 05 ）. The levels of MMP-3 significantly correlated with a large tumor size（ 〉 3cm）, presence of venous invasion,and lymph node-metastasis stage （ P 〈 0. 05 ）. With upgrading of clinical-pathological stage, the serum MMP-3 level increased significantly（ P 〈 0.05 ）, but its relation to histological type, age and sex was not significant（ P 〉 0. 05 ）. Conclusion The levels of serum MMP-3 correlated significantly with invasion and metastasis of gastric carcinoma. The serum MMP-3 levels may be user to predict invasion and metastasis of gastric carcinoma preoperatively.

关 键 词：胃肿瘤 基项金属蛋白酶3 酶联免疫吸附测定 

分 类 号：R735.2[医药卫生—肿瘤]