肿瘤坏死因子相关凋亡诱导配体与肝细胞凋亡的相关性  

Relationship between tumor necrosis factor related apoptosis induced ligand and hepatocyte apoptosis

作　　者：曹丽丽[1] 李幼平[2] 

机构地区：[1]四川大学华西第二医院,四川省成都市610040 [2]四川大学华西医院移植免疫与移植工程学实验室,四川省成都市610040

出　　处：《世界华人消化杂志》2008年第23期2626-2630,共5页World Chinese Journal of Digestology

摘　　要：肿瘤坏死因子相关的调亡诱导配体是TNF家族成员之一,通过其死亡受体诱导凋亡.研究显示TRAIL/死亡受体途径参与多种肝脏病理过程,本文就TRAIL/死亡受体途径的特性、致凋亡的机制及与肝细胞凋亡关系的最新进展作一综述.Tumor necrosis factor-related apoptosis inducing ligand （Apo2L/TRAIL） is a member of the tumor necrosis factor gene superfamily that induces apoptosis through engagement of death receptors （DRs）. Recent studies have clarified that TRAIL/DR pathway was involved in severe liver diseases. In this review, we focus on the apoptosis signaling pathways stimulated by Apo2L/TRAIL and summarise its relationship with apoptosis of hepatocytes.

关 键 词：肿瘤坏死因子相关凋亡诱导配体 凋亡 肝细胞 

分 类 号：R575[医药卫生—消化系统]