GNB3基因C825T多态性与新疆和田地区维吾尔族自然长寿老人的相关性研究  

Research on association between polymorphism of GNB3 gene C825T and natural longevity in Xinjiang Uygur nationality

作　　者：穆叶赛.尼加提 邱长春[2] 程祖亨[1] 牛文全[2] 

机构地区：[1]新疆医科大学附属第一医院心内科,新疆乌鲁木齐830054 [2]中国医学科学院基础医学研究所医学分子生物学国家重点实验室,北京100005

出　　处：《国际内科学杂志》2008年第8期438-441,共4页International Journal of Internal Medicine

基　　金：国家自然科学基金资助项目(30160089);美国中华医学基金资助项目(CMB96-657)

摘　　要：目的探讨GNB3基因C825T多态性与新疆和田地区维吾尔族老人长寿的关系。方法采用聚合酶链反应-限制性片段长度多态法(PCR-RFLP)和直接测序法检测百岁组(年龄不小于100岁)65例和长寿组(90～99岁)100例老人GNB3基因825位点的基因型,对照组112例(年龄不超过70岁自然死亡人群)作为对照组。结果百岁组和对照组GNB3825C/T的基因型和等位基因频率分布差异均具有统计学意义(P=0.0021,P<0.0001)。其中百岁组CC基因型的频率为60.0%,对照组为36.6%(OR2.60;95%CI1.39～4.89)。结论本研究初步表明,新疆和田地区维吾尔族人GNB3基因C825T多态性与个体寿命密切相关,但同时也应考虑长寿是年龄依赖的多种因素影响的结果。Objective To explore the relationship between distribution of C825T polymorphisms of GNB3 gene and natural longevity in Xinjiang Uygur nationality. Methods Polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） and direct sequencing technique were used to test C/T polymorphisms of GNB3 gene in 65 centenarians and 100 cases of people aged 90-99,112 cases of natural death aged 65-70 were used as controls. Results The fiequency of C/T polymorphisms and alleles had significantly difference between the centenarian group and controls （P=0.0021. P 〈0.0001）. The frequency of C/C genotype of the centenarian group was significantly higher than that of control group （ 60. 0% vs 36. 6% , OR 2.60 ; 95% CI 1.39-4.89）, however, it had no significant difference between the centenarian group and the group aged 90-99 （P〉0.05）. Conclusion GNB3 gene polymorphism is closely correlated with life span of individuals in Xinjiang Uygur nationality, while longevity is age dependent and influenced by multiple factors.

关 键 词：基因 维吾尔族 GNB3 长寿 

分 类 号：R394.3[医药卫生—医学遗传学]