CD154/CD40与肿瘤关系的研究进展  

Development of research on the relationship between CD154/CD40 and tumor

作　　者：岳秀[1] 蒋幼凡[1] 

机构地区：[1]重庆医科大学附属第二医院呼吸内科,重庆400016

出　　处：《国际内科学杂志》2008年第8期469-472,共4页International Journal of Internal Medicine

摘　　要：CD154及CD40是肿瘤坏死因子受体超家族成员。目前认为它们具有促进肿瘤发生发展的作用,其机制包括抗凋亡、促进新生血管形成、激活核转录因子NF-κB、上调细胞因子等多个方面。CD154及CD40与肿瘤的关系不仅成为新的研究热点,而且为肿瘤的靶向治疗提供了新的研究方向。CD154 and CD40 are members of the tumor necrosis factor receptor superfamily. Recent studies have shown they play an important role in the formation and development of tumor through mechanisms including in-hibition of apoptosis, promotion of angiogenesis, activation of NF-kB, and up-regulation of cytokines. CD154 and CD40 became a new hotspot in tumor research and provided a new target for tumor therapy. This review summarized the relationship between CD154/CD40 and tumor.

关 键 词：CD154 CD40 生物学特性 肿瘤 

分 类 号：R730.23[医药卫生—肿瘤]