^(99)Tc^m标记的肿瘤血管化特异性多肽的实验研究  

A study on anti-angiogenesis peptides labeled with ^(99)Tc^m

作　　者：刘慈懿[1] 曾骏[1] 黄钢[1] 

机构地区：[1]上海交通大学医学院附属仁济医院核医学科,上海200001

出　　处：《核技术》2008年第9期692-697,共6页Nuclear Techniques

摘　　要：本文旨在寻找一种的99Tcm标记的抗肿瘤血管化的显像剂。将具抗肿瘤血管化的多肽适当修饰后,用99Tcm标记,并在肿瘤荷鼠体内筛选比较。选择在肿瘤部位放射性浓聚明显的多肽,进行肿瘤荷鼠的体内分布和竞争试验。GPRPAA(D)A(D)-HYNIC-99Tcm标记率高、产物稳定,放化纯度>98%,室温下6h后>93%。能在荷鼠肿瘤组织较快浓聚,0.5h时肿瘤%ID/g为13.5973±1.3642,清除较慢,6h肿瘤%ID/g仍有4.0399±0.5876;血及其它血供丰富的组织清除较快,1h时血ID/g为1.7035±0.2742,心%ID/g为3.2578±1.3121,肿瘤在2h显像清晰。GPRPAA(D)A(D)-HYNIC-99mTc有希望成为一种肿瘤血管化显像剂。This work was aimed at finding a ^99Tc^m-labeled tracer for tumor angiogenesis studies. Anti-angiogenesis peptides, with appropriate structural modified, were labeled with ^99Tc^m and screening in vivo on the tumor-bearing mice. The anti-angiogenesis peptide that has the highest accumulation of radioactivity in tumor was chosen for the tissue distribution and tumor competition on the tumor bearing mice. The GPRPAA（D）A（D）-HYNIC-^99Tc^m had strong activity distribution in tumor with very low background activities in other tissues, and was quite stable with high radio labeling ratio. GPRPAA（D）A（D）-HYN/C-^99Tc^m could become a tracer of tumor angiogenesis.

关 键 词：^99TC^M标记 抗肿瘤血管化 多肽 肿瘤显像剂 动物试验 

分 类 号：R817.9[医药卫生—影像医学与核医学]