PD-L1分子与疾病免疫调节  

PD-L1 and immune regulation

作　　者：邵永[1] 王槐志[1] 董家鸿[1] 

机构地区：[1]第三军医大学西南医院肝胆外科研究所,重庆400038

出　　处：《免疫学杂志》2008年第5期591-594,共4页Immunological Journal

基　　金：国家自然科学基金资助项目(30400418);重庆市自然科学基金重点资助项目(CSTC;2005BA5004)

摘　　要：PD-L1(曾命名为B7-H1)是迄今发现的B7家族中较新的共刺激分子,与T细胞上的配体(PD-1)结合后可调节T细胞的活化及分化。它通过激活初始T细胞、抑制活化的效应T细胞及调节细胞因子的分泌等而参与多种免疫过程。以PD-L1为靶点的免疫调节与动物器官移植排斥反应、自身免疫性疾病、慢性病毒感染、肿瘤免疫逃逸等疾病的发生、发展密切相关。本文就PD-L1在上述疾病中发生、发展及治疗中的作用做一综述。Programmed death ligand-1 （PD-L1） is a new costimulatory molecule of 137 family, which can regulate T cell activation and differentiation. Effector T cell activation and cytokine production were inhibited by the interaction of PD-L1 and programmed death-1 （PD-1）. PD-L1 has an important implication on chronic viral infeetion, cancers, trans- and auto-immune diseases. Targeting PD-L1 might be a premising approach to immunosuppressive therapy in the future. Tnis article reviews the role of PD-L1 in the development and treatment of these diseases.

关 键 词：PD-L1 PD-1 免疫调节 

分 类 号：R392.11[医药卫生—免疫学]