线粒体解偶联蛋白UCP2的研究进展  

Advances in the study of mitochondrial uncoupling protein 2

作　　者：周辉[1] 张旭家[1] 

机构地区：[1]中国科学院生物物理研究所,北京100101

出　　处：《生命科学》2008年第4期549-559,共11页Chinese Bulletin of Life Sciences

基　　金："973"项目(2004CB720000)

摘　　要：本文综述了线粒体解偶联蛋白2(uncoupling protein 2,UCP2)研究方面的进展。UCP2定位于线粒体内膜上,通过消散线粒体内膜的质子梯度调节线粒体的功能,包括线粒体内膜电位、ATP合成、呼吸链ROS产生、线粒体钙库的存储和释放等。目前,UCP2的质子漏机理并不清楚,但体内实验表明UCP2活性可被过氧化物激活。特别是近年来UCP2调控胰岛素分泌方面的研究取得了重要进展。Advance researches in uncoupling protein2 （UCP2） which located in mitochondria inner membrane were reviewed. Through dissipating proton across the inner membrane, UCP2 can participate in many mitochondrial functions such as ATP synthesis, ROS production, mitochondrial calcium infusion and release. It was already known that UCP2 can be activated by reactive oxygen species （ROS）, while the detailed mechanism of proton translocation by UCP is still unclear. Furthermore, the recent advances in regulation insulin secretion from pancreatic islets by UCP2 were also discussed.

关 键 词：UCP2 解偶联蛋白 线粒体 质子漏 

分 类 号：R749.1[医药卫生—神经病学与精神病学] Q244[医药卫生—临床医学]