GRTH基因SNPrs551373与严重少精症的相关性  

Association between Polymorhism of SNPrs551373 in GRTH Gene and Severe Oligospermia

作　　者：阿周存[1] 杨琳[1] 

机构地区：[1]大理学院生命科学与化学学院,云南大理671000

出　　处：《大理学院学报（综合版）》2008年第8期1-3,共3页Journal of Dali University

基　　金：国家自然科学基金资助项目(30770809)

摘　　要：目的:研究GRTH基因的单核苷酸多态位点(SNP)rs551373(G>T)的多态性与严重少精症的关系。方法:用PCR-RFLP技术,在119例严重少精症患者和252个正常生育男性中,对SNPrs551373的基因频率和基因型频率的分布进行调查。结果:严重少精症患者中基因型GG的频率明显低于正常男性(72.3%vs.83.3%,P=0.013,OR=0.503,95%CI 0.299～0.848);而等位基因T(13.7%vs.8.7%,P=0.021,OR=1.742,95%CI 1.082～2.807)和基因型GT(26.9%vs.15.9%,P=0.012,OR=1.949,95%CI 1.150～3.304)的频率则显著高于正常男性。结论:GRTH基因的SNPrs551373的多态性与严重少精症的易感性相关。Objective： To study the relationship between the single nucleotide plymorpism （SNP） rs551373（G〉T） in gonadotropin- regulated testicular RNA helicase （GRTH） gene and severe oligospermia. Methods： The allele and genotype frequencies of SNP rs551373 were investigated in 119 patients with severe oligospermia and 252 normal men as controls by polymorase chain reaction and polymerase chain reaction-restriction fragment length polyphism analysis （PCR-RFLP）. Results： The frequency of genotype GG decreased significantly in patients with severe oligospermia compared with normal men （72.3% vs. 83.3%, P=0.013, OR=0.503,95% CI 0.299-0.848）, while the frequencies of allele T （13.7% vs.8.7%, P=0.021, OR=1.742,95% CI 1.082-2.807）and genotype GT （26.9% vs. 15.9% ,P=0.012, OR=1.949, 95% CI 1.150-3.304） in patients were significantly higher than those in controls. Conclusion： The polymorphism of SNP rs551373 in GRTH gene was associated with the susceptibility to severe oligospermia.

关 键 词：GRTH基因 单核苷酸多态 严重少精症 

分 类 号：R394[医药卫生—医学遗传学]