猕猴MHC研究及在AIDS动物模型中的意义  

Advances in research of rhesus macaque MHC and its significance in animal models of AIDS

作　　者：戴正喜[1] 张高红[1] 郑永唐[1] 

机构地区：[1]中国科学院昆明动物研究所动物模型和人类疾病机理重点实验室(硕士研究生),昆明650223

出　　处：《国际免疫学杂志》2008年第5期334-339,共6页International Journal of Immunology

基　　金：国家重点基础研究发展计划（2006CB504208）;中国科学院“西部之光”和知识创新工程重要方向项目（KSCX1-YW-R-15）;云南省科技攻关计划（2004NG12）和科技基础条件平台计划（2006PT08）

摘　　要：主要组织相容性复合体（MHC）是与免疫应答和移植排斥直接相关的一组基因群。由于MHC高度的多态性，使其在脊椎动物的免疫遗传、进化、保护以及与疾病的相关性等方面的研究倍受关注。猕猴MHC尤其是MHCⅠ类基因的组成与人类有显著差异，一个单体型中存在多个Mamu—A和Mamu—B基因。在猕猴AIDS模型中，MHC对病毒的免疫逃逸以及对AIDS疫苗的研究均有十分重要的作用，某些MHCⅠ类和MHCⅡ类基因能够显著延缓猕猴AIDS疾病的进展，为在人体中理解MHCⅠ类等位基因与免疫保护和控制病毒复制的相关性提供了一个良好的模型。The major histocompatibility complex （MHC） is a gene cluster directly related to immune response and transplant rejection. Due to the high polymorphism of the MHC genes, they gained a great deal of interest in the study of immunogenetics, evolution, and related diseases. It was demonstrated that the MHC of rhesus macaques, especially MHC Ⅰ possesses multiple Mamu-A and Mamu-B genes per haplotype, which is significantly different from that of human. In the animal models of AIDS, MHC plays an important role in the immune escape of the virus. Therefore, MHC is of vital importance in AIDS vaccine development. Certain MHC Ⅰ and Ⅱ alleles in the rhesus macaque have been implicated in the control of disease progression. As a resule, the rhesus monkeys became a good animal model in the researches on the correlation of MHC class Ⅰ allele-associated immune protection and viral replication in human.

关 键 词：猕猴 MHC 多态性 AIDS 动物模型 

分 类 号：R-332[医药卫生]