影响美沙酮维持治疗脱失的相关因素分析  

作　　者：严峻[1] 徐汉明[1] 朱军红[1] 王鹏[1] 高作惠[1] 欧阳盛[1] 刘春芳[1] 崔榕[1] 李波[1] 陈冬青[1] 

机构地区：[1]华中科技大学同济医学院附属精神卫生中心,湖北武汉430022

出　　处：《中国民康医学》2008年第18期2111-2112,2152,共3页Medical Journal of Chinese People’s Health

摘　　要：目的：探讨与美沙酮维持治疗脱失有关的危险因素。方法：回顾性分析我中心2006年8月。2008年2月收治的378例美沙酮维持治疗患者的临床资料与治疗脱失的相关性。结果：退出治疗发生率为17．99％；吸毒年限、文化程度、职业、婚姻、SSRS总分、吸毒方式、日吸毒量和药物滥用史与美沙酮维持治疗脱失明显相关（P〈0．05或P〈0．01），而性别、年龄和日吸毒频率与其脱失之间的关系不显著（P〉0．05）。结论：无业、文化程度低、社会支持程度低、药物滥用、采用注射吸毒、吸毒时间长、日吸毒量高可能是导致美沙酮维持治疗脱失的重要因素，如何提高美沙酮维持治疗的操守率，仍然是社会学和医学今后的一个重要课题。Objective： To investigate influential factor of curative escape in methadone maintenance. Methods： The clinical datas were analyzed by multiple linear regression related with the curative escape in the 378 methadone maintenance patients, From August 2006 to February 2008, were treated in our hospital. Results： The incidence rate of exodus was 17.99%. The drug abuse time limit, cultural degree, occupation, marriage, SSRS score, modality of drug abuse, amount of drug abuse everyday and substance abuse significantly correlated with the curative escape（ P 〈 0.05 or P 〈 0.01 ）, and sex, age, frequency of drug abuse everyday quietly correlated with the curative escape （ P 〉 0.05 ）. Conclusion： unemployment, low education,low social support, drug abuse, drug - injecting application,long period of drug taking. Big dosage of drug per day may be one of the factors of degrading the effectiveness of methadone maintenance therapy. How to elevate the personal integrity rate of methadone maintenance therapy is still the significant subject in the sociological and medical fields.

关 键 词：美沙酮 维持治疗 影响因素 

分 类 号：R749.69[医药卫生—神经病学与精神病学]