无抽搐电休克对精神分裂症患者血清IL-6的影响及临床意义  

Effects of MECT on serum IL-6 and clinical significance in schizophrenics

作　　者：段德香[1] 王萍[1] 赵洪祖[1] 

机构地区：[1]新乡医学院第二附属医院,河南新乡453002

出　　处：《中国民康医学》2008年第18期2115-2116,2123,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨无抽搐电休克(MECT)对精神分裂症患者血清IL-6水平的影响及与精神症状变化的关系。方法:选择符合CCMD-3标准及MECT治疗条件的住院患者31例作为研究组,分别于治疗前、治疗第4次、第8次后测定血清IL-6水平,并用PANSS量表评估精神症状。选择20例健康志愿者作为对照组。结果:IL-6水平在各个时段研究组均比对照组高(t=22.229,23.935,23.085,P均<0.05),研究组在各个时段IL-6值的变化无区别(F=1.458,P=0.238),研究组在各个时段的IL-6值和PANSS评分无相关性(总分)(r=0.257,0.216,0.268,P均>0.05),随着治疗的进展PANSS评分明显下降(P均<0.05)。结论:MECT对精神分裂症患者血清IL-6水平无影响,IL-6水平与精神症状变化无关系。Objective： To explore the effects of modified electro convulsive therapy （MECT） on serum IL - 6 and its relationship to changes of psychiatric symptoms in schizophrenics. Methods： 31 in patients meeting the CCMD - 3 criteria and M ECT treatment conditions were selected as research group and 20 healthy volunteers as control group, and serum IL - 6 levels were measured and psychiatric symptoms assessed with the Positive and Negative Syndrome Scale（PANSS） before treatment and after the 4^th and 8^th treatment. Results： IL - 6 levels of each chron - section were higer in the research than in the control group（all P 〈 0.05 ） ; in the research group, there were no differences in each chron - section changes（ P = 0. 238 ）, each chron- section values not related to the scores of PANSS（all P 〉 0.05） and the PANSS scores significantly lowered along with therapeutic advancement. Conclusion： The M ECT has no effects on serum IL- 6 levels which aren＇t reated to the changes of psychiatric symptoms in schizophrenics.

关 键 词：MECT 精神分裂症 IL-6 PANSS量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]