卵巢恶性淋巴瘤6例临床病理分析  

Ovarian malignant lymphoma:a clinicopathologic analysis of 6 cases

作　　者：顾芸[1] 程静[1] 张正祥[1] 马捷[1] 周航波[1] 马恒辉[1] 李凤山[2] 石群立[1] 

机构地区：[1]南京军区南京总医院病理科 [2]南京市妇幼保健院

出　　处：《诊断病理学杂志》2008年第4期266-268,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨卵巢恶性淋巴瘤的临床病理特点和鉴别诊断。方法分析6例卵巢恶性淋巴瘤的临床资料及组织病理学和免疫表型特点,按WHO(2001)淋巴造血组织肿瘤分类进行组织学分型。结果6例患者平均年龄51岁,临床主要表现为腹痛和腹部包块。6例均诊断为弥漫性大B细胞性淋巴瘤,其组织学特点是瘤细胞弥漫分布,细胞大,核圆形或卵圆形,核膜厚,可见核仁。免疫组化:肿瘤细胞CD20、CD79a和MUM-1弥漫(+),CD3、CD43、MPO、CD117、PLAP和TdT均(-)。结论卵巢淋巴瘤极少见,确诊依赖组织学和免疫组化检测。该病需要和粒细胞肉瘤、无性细胞瘤、小细胞癌等鉴别。Objective To investigate the clinicopathologic features and differential diagnosis of ovarian malignant lymphoma. Methods The medical records, histopathologic features and immunophenotype of ovarian malignant lymphoma were analyzed in six cases. The diagnosis and histological classification were referred to the criteria of the World Health Organization classification for turnouts of the hematopoietic and lymphoid tissues （2001）. Results The mean age of the 6 patients was 51 years old. The major clinical manifestations were abdominalgia and abdominal mass. Six patients were diagnosed as diffuse large B-cell lymphoma. Tumor cells showed a diffuse growth pattern. The large nuclei were round or oval shape with thick nuclear membrane and clear nucleoli. The tumor cells expressed CD20, CD79a and MUM-l, while CD3, CD43, MPO, CD117, PLAP and TdT were negative. Conclusion Ovarian lymphoma is uncommon. The diagnosis depends on the histologic and detection and it should be distinguished from granulocytic sarcoma, dysgerminoma and small cell carcinoma.

关 键 词：卵巢 淋巴瘤 免疫组化 诊断 鉴别诊断 

分 类 号：R737.31[医药卫生—肿瘤]