子宫内膜微腺性腺癌临床病理观察  

Microglandular adenocarcinoma of endometrium:a clinicopathologic observation

作　　者：黄文斌[1] 罗新华[1] 黄悦[1] 赵建华[1] 李俐[1] 王劲松[1] 熊克美[1] 

机构地区：[1]南京医科大学附属第一医院病理科,南京210006

出　　处：《诊断病理学杂志》2008年第4期283-286,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨子宫内膜微腺性腺癌的临床病理特征、免疫表型及其鉴别诊断。方法对1例子宫内膜微腺性腺癌进行光镜和免疫组化检测。结果组织学上,肿瘤主要由排列致密的微小腺体组成,细胞胞质中等、透亮、嗜酸性,核圆形或卵圆形,核分裂象少。腺腔、腺上皮和间质内可见大量中性粒细胞浸润。免疫组化示肿瘤细胞CK、EMAv、imentin、mCEA和ER(+),而PRp、16和p53(-),Ki-67增殖指数>10%。结论子宫内膜微腺性腺癌是子宫内膜癌一种少见的特殊类型,形态学非常类似于宫颈的微腺体增生,刮宫标本中极易误诊,免疫组化可有助于正确诊断。Pro＇pose To explore the clinical pathologic feature, s, immunophenotype and differentiatial diagnosis of endometrial microglandular adenocarcinoma. Methods A case of microglandular adenocarcinoma of endometrium was analysed by HE and staining. Results Microscopically, the tumour was composed of closely packed microglandular structure, Them were moderate anlount of pale to eosinophilic cytoplasm with oval and round nuclei, mitoses were occasionally observed Abundant neutrophils were observed within glandular lumina, epithelial cells and the intervening stroma. Immunohistochemically, the tumour cells were positive for CK, EMA, vimentin, mCEA and ER, but negative for PR, p16 and p53. The proliferative index with MIB was 〉 10%. Conclusions Endometrial microglandular adenocarcinoma is a rare type of endometrial careinoma which mimicks microglandular hyperplasia of cervix. It is easily confused with benign lesions like microglandular hyperplasia and malignant lesions of cervix in the curettage specimens. Immunohistochemical staining may assist to make a correct diagnosis.

关 键 词：子宫内膜肿瘤 子宫内膜样癌 微腺体 微腺体增生 免疫组化 

分 类 号：R737.3[医药卫生—肿瘤]