肺上皮样血管内皮瘤临床病理观察  

Pulmonary epithelioid haemangioendothelioma:clinicopathologic observations

作　　者：戴林[1] 郑红芳[1] 宋秋静[1] 

机构地区：[1]北京大学人民医院病理科,北京100044

出　　处：《诊断病理学杂志》2008年第4期294-296,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的报道1例罕见的孤立性肺上皮样血管内皮瘤并进行文献复习,寻找可能与肿瘤预后有关的因素。方法对本肿瘤的临床表现、影像学、病理形态及免疫组化进行详细的观察。结果肺上皮样血管内皮瘤以微息肉样充满肺泡腔,肿瘤细胞内可见含有红细胞的胞质空泡;在黏液样或玻璃样变的背景中上皮样肿瘤细胞呈巢索状不规则分布。肿瘤可以出现梭形细胞分化。结论肺上皮样血管内皮瘤好发于年轻女性。典型表现为双肺多发小结节。肿瘤为低度恶性,但当其临床症状重、肿瘤转移、细胞异型明显、核分裂活跃、出现梭形细胞成分时,临床预后差。Objective To report 1 ease of solitary epithelioid haemangioendothelioma of lung with review of hterature and to find out the prognostic factors related to the tumor. Methods The clinical, imaging, pathological and features of this neoplasm were described in detail. Results The tumor filled alveoh in a contiguous micropolypoid fashion. Some of cells displayed intracytoplasmie lumina containing erythrocytes. The tumor was composed of rounded or spindled eosinophilie endothelial cells arranged in small nests or cords embedded in a sulfated acid-rich matrix which varied from a light blue to deep pink eolour. The tumor had spindle cell differentiation. Conclusions The typical radiological appearance reveals multiple bilateral lung nodules in young women. Pulmonary epithelioid hemangioendothelioma is designated low grade malignancy. Severe clinical symptoms, tumor matastasis, marked nulear atypia, mitotic activity, spindling of the cells and necrosis are considered to be significant factors for poor prognosis.

关 键 词：肺上皮样血管内皮瘤 临床 组织病理学 

分 类 号：R734.2[医药卫生—肿瘤]