血红素加氧酶1基因多态性与血压水平的关系分析  

Effect of the genetic variants of heme oxygenase-1 gene on blood pressure level in hypertensive patients.

作　　者：李云[1] 刘晓丽[1] 王来元[1] 曹杰[1] 李建新[1] 鲁向锋[1] 黄建凤[1] 顾东风[1] 

机构地区：[1]中国协和医科大学中国科学医学院阜外心血管病医院循证医学部和群体遗传研究室,北京100037

出　　处：《中国综合临床》2008年第10期966-969,共4页Clinical Medicine of China

基　　金：国家973计划项目（2006CB503805）;国家863项目（2006AA02Z170）;北京市自然科学基金项目（7061006）

摘　　要：目的探讨血红素加氧酶1基因多态性与血压水平的关系。方法采用标签SNP策略，选择血红素加氧酶1基因的3个标签SNP位点进行研究。在503例原发性高血压患者中对这3个位点进行基因分型，采用方差分析比较各位点不同基因型个体血压水平的差异，采用haplo．stats软件计算单体型频率并检验其与血压水平的关系。结果血红素加氧酶1基因rs2071749位点A等位基因携带者收缩压和舒张压水平分别为159．5mmHg和97．6mmHg，GG基因型携带者收缩压和舒张压水平分别为168．5mmHg和101．3mmHg，差异有统计学意义（P〈0．05）。多因素回归分析进一步证实了该结果。单体型分析结果显示在调整年龄、性别、体质指数、吸烟和饮酒等危险因素后，含有rs2071749A等位基因的单体型T—T-A与收缩压水平和舒张压水平均显著相关。结论血红素加氧酶1基因多态可能对血压水平有一定的影响。Objective To assess the relationship between the polymorphisms of heme oxygenase-1 gene and blood pressure level. Methods With the whole-gene based tagging SNP approach,3 tag SNPs of heme oxygenase-1 gene were selected for study. These tag SNPs were genotyped in 503 essential hypertension cases. Blood pressure levels among different genotypes of each SNP were compared with ANOVA. The haplo, stats program was employed to test haplotype frequency with blood pressure level. Results Subjects with rs2071749 A allele had the lower blood pressure levels than subjects with GG genotypes （ SBP： 159.5 mm Hg vs. 168.5 mm Hg and DBP：97.6 mm Hg vs. 101.3 mm Hg respectively,P 〈0.05 ）.In the haplotype analyses,Haplotype T-T-A which carried the rs2071749 A allele was found significantly associated with SBP and DBP after adjustment for age,gender, body mass index, smoking and drinking. Conclusion The genetic variants of heme oxygenase-1 gene might be associated with blood pressure levels.

关 键 词：血红素加氧酶 多态性 单体型 血压 标签SNP 

分 类 号：R544.1[医药卫生—心血管疾病]