结直肠癌p16/MTS1基因纯合缺失的研究  

Study of p16/MTS1 gene inactivation in colorectal carcinoma

作　　者：康旭[1] 冼沛中[1] 徐飞鹏[1] 

机构地区：[1]广东医学院附属医院胃肠外科,湛江524001

出　　处：《结直肠肛门外科》2008年第4期252-254,共3页Journal of Colorectal & Anal Surgery

基　　金：广东医学院青年基金资助项目.项目编号:2006018

摘　　要：目的探讨p16/MTS1基因结合缺失与结直肠癌的发生及临床病理关系。方法采用聚合酶链反应方法,对68例结直肠癌组织中p16/MTS1基因纯合缺失进行检测。并用Fisher精确检验的方法,对p16/MTS1基因纯合缺失与临床病理关系进行统计分析。结果68例结直肠癌组织,p16/MTS1基因纯合缺失率为35.29%。DuckesC、D期的缺失率明显高于DuckesA、B期(P<0.05)。低分化腺癌p16/MTS1基因纯合缺失率(11/16)高于高分化腺癌肿瘤(4/25)(P<0.05)。侵犯到浆膜及浆膜外者p16/MTS1基因纯合缺失率高于侵犯在浆膜内者(P<0.05)。结论p16/MTS1基因纯合缺失与结直肠癌的临床分期、病理分化、肌层浸润等生物学特征有关。Objective To probe the expression of p16/MTS1 gene in colorectal carcinoma. Methods Homozygous deletion of p16/MTS1 gene was examined by PCR methods in 68 cases of colorectal carcinoma. Resuits 35.29% homozygous deletion of p16/MTS1 gene was found in carcinoma of colorectal. The rate of homozygous deletion of p16/MTS1 in Dukes C, D stages was significantly higher than that in Dukes A, B stages（ P 〈0.05）, p16/MTS1 gene homozygous deletion was higher in poorly differentiated carcinoma than that in well differentiated carcinoma. Conclusion There is a relationship between homozygous deletion of p16/MTS1 gene and clinicalpathological features of colorectal carcinoma.

关 键 词：结直肠癌 P16/MTS1 抑癌基因 

分 类 号：R735.3[医药卫生—肿瘤]