聚N-异丙基丙烯酰胺水凝胶的微波合成及其药物控释性研究  

Studies on Synthesis of Poly(N-Isoproprylacrylamide) Thermo-Responsive Hydrogels by Microwave and Vitro Release

作　　者：张建州[1] 卢艳霞[1] 谢建刚[1] 毛海荣[1] 

机构地区：[1]郑州师范高等专科学校化学系,郑州450044

出　　处：《河南科学》2008年第9期1033-1035,共3页Henan Science

基　　金：河南省科技厅科技攻关项目(624440053)

摘　　要：用微波引发合成了聚N-异丙基丙烯酰胺,并制成整体型释放器,对非水溶性药物阿昔洛韦在不同温度响应时的药物缓释行为进行了研究.Fast responsive thermosensitive PNIPA hydrogels were synthesized by using free radical polymerization in microwave oven. Such hydrogels swelled or shrank same fast in response to the chang of temperature as conventional hydrogels. Acyclovir is a broad-spectrum antivirus. PNIPA hydrogel with acyclovir was tested for drug release. It was identified that hydrogel as drug matrixes could deliver longer and more validly.

关 键 词：聚N-异丙基丙烯酰胺 阿昔洛韦 微波 药物控释 

分 类 号：R944.9[医药卫生—药剂学]