MGMT和EGFR在乳腺癌中的表达及其相关性分析  

An Analysis on Expressions of MGMT and EGFR and Their Correlation in Breast Cancer

作　　者：王发亮[1] 薄爱华[2] 吴力娟[1] 朱玉平[1] 张丽丽[1] 

机构地区：[1]河北北方学院大学生科协,河北张家口075029 [2]河北北方学院实验中心电镜室,河北张家口075029

出　　处：《中国肿瘤》2008年第9期816-817,共2页China Cancer

基　　金：河北省科技厅攻关项目(03276117)

摘　　要：[目的]研究乳腺癌组织中DNA修复酶O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)和表皮生长因子受体(EGFR)表达的相关性及其临床意义。[方法]采用免疫组织化学SABC法,检测66例乳腺癌组织中MGMT及EGFR的表达。[结果]乳腺癌中MGMT的阳性率为57.58%,EGFR的阳性率为48.48%,MGMT与EGFR的表达具有中度相关性(r=0.403)。有淋巴结转移患者MGMT与EGFR阳性率均高于无转移(P<0.05)。[结论]检测MGMT与EGFR的表达对乳腺癌患者的预后判断和制定化疗方案具有指导意义。[Purpose] To explore the correlation between O^6-methyguanine-DNA methytransferase （MGMT） and epidermal growth factor receptor（EGFR） in breast cancer and its clinical significance. [Methods]The expressions of MGMT and EGFR in 66 cases with breast cancer were detected by SABC immunohistochemical method. [Results] The positive rate of MGMT was 57.58% and the positive rate of EGFR was 48.48% in breast cancer. Moderate correlation between MGMT and EGFR was found（r=-0.403）. The positive rate of MGMT and EGFR in case with lymph node metastasis was higher than that without lymph node metastasis （P〈0.05）. [Conclusion] Detection on expressions of MGMT and EGFR in breast cancer play a role for planning chemotherapy regimen and prognositic evaluation.

关 键 词：乳腺肿瘤 O^6-甲基鸟嘌呤-DNA甲基转移酶 表皮生长因子受体 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]