血管生成抑制剂TNP-470抑制Lewis肺癌生长和转移的实验研究  

An experimental study of angiogenesis inhibitor TNP 470 on tumor growth and metastasis of Lewis lung carcinoma

作　　者：夏景林[1] 杨秉辉[1] 

机构地区：[1]上海医科大学中山医院肝癌研究所

出　　处：《中华肿瘤杂志》1997年第5期333-335,共3页Chinese Journal of Oncology

摘　　要：目的采用Ｌｅｗｉｓ肺癌来验证血管生成抑制剂ＴＮＰ－４７０对肿瘤生长和转移的抑制作用。方法将Ｌｅｗｉｓ肺癌细胞接种于Ｃ５７ＢＬ小鼠皮下（２．４×１０６／鼠）。将２０只小鼠随机分成对照组和治疗组，自第２天起分别给予溶剂（３％酒精）０．２ｍｌ和ＴＮＰ－４７０（４０ｍｇ／ｋｇ），隔天给药１次，共８次。第２２天时，测定对照组和治疗组的皮下瘤重及肺转移率，分别进行ｔ检验和χ２检验。结果两组皮下瘤重分别为３．７７±１．０５ｇ和１．９８±０．９６ｇ（Ｐ＝０．０００９）；两组肺转移率分别为８０％和３０％（Ｐ＝０．０３）。结论血管生成抑制剂ＴＮＰ－４７０能明显抑制Ｌｅｗｉｓ肺癌的生长和转移。Objective The inhibition effect of angiogenesis inhibitor TNP 470 on tumor growth and metastasis was studied using Lewis lung carcinoma. Methods Lewis lung carcinoma cells(2.4×10 6/mouse) were inoculated subcutaneously to 20 mice, they were randomized into 2 groups. From the 2nd day, the treated group was given 40 mg/kg of TNP 470 SC q.o.d. (8 times) and the control group was given vehicle only (3% ethanol). On the 22nd day, the weight of the subcutanous tumors and the lung metastasis rates of the 2 groups were detected. The results were analysed by Student t and χ 2 test. Results The tumor weight of the control and treated group was 3.77±1.05 g and 1.98±0.96 g,respectively ( P =0.0009). The lung metastasis rate of the control and treated group was 80%(8/10) and 30%(3/10),respectively ( P =0.03). Conclusion These results suggest that the angiogenesis inhibitor TNP 470 has a strong inhibitory effect both on growth of the primary tumor and metastasis of Lewis lung carcinoma.

关 键 词：肺肿瘤 血管生成抑制剂 TNP-470 肿瘤转移 

分 类 号：R734.205[医药卫生—肿瘤] R73－36[医药卫生—临床医学]